Targets for molecular imaging. Cell surface glycans are underexpressed with disease progression in oesophageal cancer (EAC), and can be detected with lectins. Protein targets (epidermal growth factor receptor (EGFR), ERBB2, c-MET, fibroblast growth factor receptors (FGFR) 1 and 2)) that are overexpressed in Barrett's neoplasia are accessible to imaging with peptides and antibodies. Cyclooxygenase-2 (COX-2) is an intracellular enzyme that is absent in normal cells but increased in neoplasia. Osteopontin (OPN) is a secreted extracellular matrix protein that is highly overexpressed in EAC.