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Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment
  1. Bruno Sainz Jr1,2,
  2. Sonia Alcala1,2,
  3. Elena Garcia3,4,
  4. Yolanda Sanchez-Ripoll1,
  5. Maria M Azevedo1,
  6. Michele Cioffi1,
  7. Marianthi Tatari1,
  8. Irene Miranda-Lorenzo1,
  9. Manuel Hidalgo5,
  10. Gonzalo Gomez-Lopez6,
  11. Marta Cañamero7,
  12. Mert Erkan8,9,
  13. Jörg Kleeff8,
  14. Susana García-Silva1,
  15. Patricia Sancho1,
  16. Patrick C Hermann1,10,
  17. Christopher Heeschen1,11
  1. 1Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
  2. 2Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, Madrid, Spain
  3. 3Molecular Diagnostics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
  4. 4Pathology Department, Hospital Universitario Fundacion Alcorcon, Madrid, Spain
  5. 5Gastrointestinal Cancer Clinical Research Unit, Clinical Research Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
  6. 6Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
  7. 7Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
  8. 8Department of Surgery, Klinikum rechts der Isar, Technical University, Munich, Germany
  9. 9Koc University School of Medicine, Istanbul, Turkey
  10. 10Deptartment of Internal Medicine I, Ulm University, Ulm, Germany
  11. 11Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, London, UK
  1. Correspondence to Dr Bruno Sainz Jr, Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, E-28029 Madrid, Spain; bruno.sainz@uam.es and Dr Christopher Heeschen, Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, Charterhouse Sqr, London EC1M 6BQ, UK; c.heeschen{at}qmul.ac.uk

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