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Pancreas
Original article
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment

Authors

  • Bruno Sainz Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, Madrid, Spain PubMed articlesGoogle scholar articles
  • Sonia Alcala Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, Madrid, Spain PubMed articlesGoogle scholar articles
  • Elena Garcia Molecular Diagnostics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Pathology Department, Hospital Universitario Fundacion Alcorcon, Madrid, Spain PubMed articlesGoogle scholar articles
  • Yolanda Sanchez-Ripoll Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Maria M Azevedo Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Michele Cioffi Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Marianthi Tatari Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Irene Miranda-Lorenzo Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Manuel Hidalgo Gastrointestinal Cancer Clinical Research Unit, Clinical Research Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Gonzalo Gomez-Lopez Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Marta Cañamero Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Mert Erkan Department of Surgery, Klinikum rechts der Isar, Technical University, Munich, Germany Koc University School of Medicine, Istanbul, Turkey PubMed articlesGoogle scholar articles
  • Jörg Kleeff Department of Surgery, Klinikum rechts der Isar, Technical University, Munich, Germany PubMed articlesGoogle scholar articles
  • Susana García-Silva Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Patricia Sancho Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Patrick C Hermann Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Deptartment of Internal Medicine I, Ulm University, Ulm, Germany PubMed articlesGoogle scholar articles
  • Christopher Heeschen Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Bruno Sainz Jr, Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, E-28029 Madrid, Spain; bruno.sainz@uam.es and Dr Christopher Heeschen, Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, Charterhouse Sqr, London EC1M 6BQ, UK; c.heeschen{at}qmul.ac.uk
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Citation

Sainz B, Alcala S, Garcia E, et al
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment
Gut 2015;64:1921-1935.

Publication history

  • Received December 1, 2014
  • Revised March 15, 2015
  • Accepted March 16, 2015
  • First published April 3, 2015.
Online issue publication 
October 26, 2017

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