Footnotes

• Correction notice This article has been corrected since it was published Online First. The Funding statement has been amended.

• Acknowledgements The authors would like to thank Dr S Middendorp, Prof E Nieuwenhuis and Prof H Clevers (Utrecht, the Netherlands) for their help and advice in setting up the intestinal organoid cultures.

• Contributors JVL: study design, performed experiments, wrote manuscript. KG: study design, performed experiments, manuscript preparation. PH: genotyping, data analysis, manuscript preparation. RKR: patient and data collection, manuscript preparation. HED: patient and data collection, genotyping quality control, data analysis. JS: patient and data collection, study design, manuscript review. AMG: supervisor of experiments, study design, manuscript preparation. DJP: study design, supervisor of experiments, manuscript preparation. DCW: study design, genotyping, patient and data collection, manuscript preparation.

• Funding JVL was supported by a Canadian Institutes for Health Research (CIHR)/Canadian Association of Gastroenterology Fellowship (234622), the University of Toronto Edward Christie Stevens Fellowship, Nellie L Farthing Fellowship, the William S Fenwick Fellowship, the Chisholm Memorial Fellowship, the Miriam Neveren Memorial Award and the Joseph M West Family Memorial Fund, and was the holder of the 2011 CIHR Bisby Fellowship. DP is a Howard Hughes International Scholar and is supported by the CIHR and Canadian Crohn's and Colitis Foundation (CCFC). PH was supported by a Medical Research Council project grant for PICTS to DW (G0800675), by Schering-Plough and the GI/Nutrition Research Fund, Child Life and Health, University of Edinburgh. RKR is supported by a NHS Research Scotland career fellowship award.

• Competing interests None.

• Ethics approval COREC.

• Provenance and peer review Not commissioned; internally peer reviewed.

• Data sharing statement CD24 genotyping: only female patients and controls were analysed due to pseudogene on the Y chromosome.