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LV and GP contributed equally to this work.
Contributors LV, GC, CL and GP conceived and designed the study and experiments. MN, MP, IB, OC, SG, CL, GC and LV collected data, performed genetic analyses, and provided samples and clinical data. NS, MG, FB, NK, OC, GP and LV performed the experiments and analysed the results. XSP, RV-M and AL-D analysed the next-gen sequencing data. LV and GP wrote the manuscript. All authors critically reviewed the manuscript and provided final approval.
Funding This work was funded by the Spanish Ministry of Economy and Competitiveness (State Secretariat for Research, Development and Innovation) (grants SAF2012-38885 and SAF2010-21165 to LV and XSP, Ramón y Cajal contract to LV, fellowship to FB, and RTICC networks RD12/0036/0031 and RD12/0036/0008); the Deutsche Krebshilfe (grant 110799 to GP); the Carlos III Health Institute (fellowship to NS); L'Oréal-UNESCO “For Women in Science”; the Scientific Foundation Asociación Española Contra el Cáncer; and the Government of Catalonia (grant 2009SGR290).
Ethics approval IDIBELL Ethics Committee.
Provenance and peer review Not commissioned; internally peer reviewed.