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We acknowledge Cao et al 1 for being interested in our recent study on molecular features of hepatitis B related hepatocellular carcinoma (HBV-related HCC).2 As they suggested, we searched for the HBx-LINE1 chimerical transcript recently identified in a Chinese population of HBV-related HCC by Lau et al 3 in our series of HCC treated in France.2 To this aim, we have selected and analysed 50 HBV-related HCC tumours which were included in our last report.2 Total RNAs were extracted using Trizol (Invitrogen) from frozen tissues and converted into …
Contributors All authors performed the experiments, analyses and have written the letter.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; internally peer reviewed.