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Authors’ response: virus–host interactions in HBV-related hepatocellular carcinoma: more to be revealed?
  1. Qian Cao1,2,3,4,
  2. Sandrine Imbeaud1,2,3,4,
  3. Shalini Datta1,2,3,4,
  4. Jessica Zucman-Rossi1,2,3,4,5
  1. 1 Inserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France
  2. 2 Faculté de Médecine, Université Paris Descartes, Labex Immuno-oncology, Sorbonne Paris Cité, Paris, France
  3. 3 Université Paris 13, Sorbonne Paris Cité, UFR SMBH, Bobigny, France
  4. 4 Université Paris Diderot, Paris, France
  5. 5 Assistance Publique-Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France
  1. Correspondence to Professor Jessica Zucman-Rossi, Inserm U1162, Génomique fonctionnelle des tumeurs solides, 27 rue Juliette Dodu, Paris 75010, France; jessica.zucman-rossi{at}

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We acknowledge Cao et al 1 for being interested in our recent study on molecular features of hepatitis B related hepatocellular carcinoma (HBV-related HCC).2 As they suggested, we searched for the HBx-LINE1 chimerical transcript recently identified in a Chinese population of HBV-related HCC by Lau et al 3 in our series of HCC treated in France.2 To this aim, we have selected and analysed 50 HBV-related HCC tumours which were included in our last report.2 Total RNAs were extracted using Trizol (Invitrogen) from frozen tissues and converted into …

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  • Contributors All authors performed the experiments, analyses and have written the letter.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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