Increased severity of caerulein-induced acute pancreatitis in Mnk1−/− mice. (A) Histology of wild type (WT) and knockout (KO) pancreata during acute pancreatitis (inflammatory cell infiltration 2 days after pancreatitis induction is indicated by arrowheads and shown in higher magnification insets). (B) Number of MPO+ cells/field (100×) in sections of WT and KO pancreata 2 days after pancreatitis induction (n>5). (C) Immunohistochemical staining of MPO+ cells in WT and KO pancreata 2 days after pancreatitis induction. (D) Serum amylase activity in WT and KO mice during acute pancreatitis. (E) mRNA expression dynamics of acinar genes in WT and KO pancreata upon acute pancreatitis detected by RT-qPCR (n>3); *p<0.05, **p<0.01.