Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice

J D Coombes; M Swiderska-Syn; L Dollé; D Reid; B Eksteen; L Claridge; M A Briones-Orta; S Shetty; Y H Oo; A Riva; S Chokshi; S Papa; Z Mi; P C Kuo; R Williams; A Canbay; D H Adams; A M Diehl; L A van Grunsven; S S Choi; W K Syn

doi:10.1136/gutjnl-2013-306484

Article info

Hepatology

Original article

Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice

Authors

J D Coombes Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK PubMed articles Google scholar articles
M Swiderska-Syn Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina, USA PubMed articles Google scholar articles
L Dollé Faculty of Medicine and Pharmacy, Liver Cell Biology Lab (LIVR), Department of Cell Biology (CYTO), Vrije Universiteit Brussel, Brussels, Belgium PubMed articles Google scholar articles
D Reid Snyder Institute for Chronic Diseases, Health Research and Innovation Centre (HRIC), University of Calgary, Calgary, Canada PubMed articles Google scholar articles
B Eksteen Snyder Institute for Chronic Diseases, Health Research and Innovation Centre (HRIC), University of Calgary, Calgary, Canada PubMed articles Google scholar articles
L Claridge Centre for Liver Research, NIHR Institute for Biomedical Research, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
M A Briones-Orta Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK PubMed articles Google scholar articles
S Shetty Centre for Liver Research, NIHR Institute for Biomedical Research, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
Y H Oo Centre for Liver Research, NIHR Institute for Biomedical Research, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
A Riva Viral Hepatitis Group, The Institute of Hepatology, Foundation for Liver Research, London, UK PubMed articles Google scholar articles
S Chokshi Viral Hepatitis Group, The Institute of Hepatology, Foundation for Liver Research, London, UK PubMed articles Google scholar articles
S Papa Cell Signaling Group, The Institute of Hepatology, Foundation for Liver Research, London, UK PubMed articles Google scholar articles
Z Mi Department of Surgery, Loyola University, Chicago, USA PubMed articles Google scholar articles
P C Kuo Department of Surgery, Loyola University, Chicago, USA PubMed articles Google scholar articles
R Williams Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK PubMed articles Google scholar articles
A Canbay Department of Gastroenterology and Hepatology, Essen University Hospital, Essen, Germany PubMed articles Google scholar articles
D H Adams Centre for Liver Research, NIHR Institute for Biomedical Research, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
A M Diehl Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina, USA PubMed articles Google scholar articles
L A van Grunsven Faculty of Medicine and Pharmacy, Liver Cell Biology Lab (LIVR), Department of Cell Biology (CYTO), Vrije Universiteit Brussel, Brussels, Belgium PubMed articles Google scholar articles
S S Choi Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina, USA Section of Gastroenterology, Department of Medicine, Durham Veteran Affairs Medical Center, Durham, North Carolina, USA PubMed articles Google scholar articles
W K Syn Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK Centre for Liver Research, NIHR Institute for Biomedical Research, University of Birmingham, Birmingham, UK Department of Hepatology, Barts Health NHS Trust, London, UK PubMed articles Google scholar articles

Correspondence to Dr Wing-Kin Syn, The Institute of Hepatology, Foundation for Liver Research, London WC1E 6HX, UK; wsyn{at}doctors.org.uk

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Citation

Coombes JD, Swiderska-Syn M, Dollé L, et al

Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice

Gut 2015;64:1120-1131.

Publication history

Received November 25, 2013
Revised May 5, 2014
Accepted May 22, 2014
First published June 5, 2014.

Online issue publication

October 26, 2017

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