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Altered microbiota in microscopic colitis
  1. Hans Fischer1,
  2. Elisabet Holst1,
  3. Fredrik Karlsson2,
  4. Cecilia Benoni3,
  5. Ervin Toth3,
  6. Martin Olesen4,
  7. Måns Lindén1,
  8. Klas Sjöberg3
  1. 1 Department of Clinical Sciences, Department of Microbiology, Skåne University Hospital, Lund University, Lund, Sweden
  2. 2 Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
  3. 3 Department of Clinical Sciences, Department of Gastroenterology and Nutrition, Skåne University Hospital, Lund University, Malmö, Sweden
  4. 4 Department of Pathology, University and Regional Laboratories Region Skåne, Skåne University Hospital, Malmö, Sweden
  1. Correspondence to Dr Klas Sjöberg, Department of Clinical Sciences, Department of Gastroenterology and Nutrition, Skåne University Hospital, Lund University, Malmö SE-205 02, Sweden; klas.sjoberg{at}

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Recently, Shin et al1 reported that Akkermansia spp had a beneficial effect on glucose homeostasis in obese mice. Mucin degrading Akkermansia—promoting mucin degradation and turnover—is associated with a healthy mucosa. In IBD, a deranged microbiota is reported while findings in microscopic colitis (MC) are lacking. MC is a disorder characterised by chronic non-bloody diarrhoea, predominantly affecting elderly smoking women. Despite frequent diarrhoea, laboratory anomalies are seldom seen.

Since an altered microbiota is reported in several immune mediated diseases and since MC affects the gut, our hypothesis was that the microbiota would be altered in patients with MC.

A group of 10 female patients (mean age 48 years, range 43–68 years) with onset of MC collected as previously described2 donated faecal samples that were compared with samples from seven healthy control women (mean age 50 years, range 45–65 years) with respect to their faecal microbiota.

The bacterial microbiome was analysed by DNA sequencing (Illumina Hiseq 2000) and sequences were aligned to a …

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  • Contributors Conception and design: HF, EH, CB, ET, MO and KS. Development of methodology: HF and FK. Acquisition of data: HF, EH, CB, ET, MO, ML and KS. Analysis and interpretation of data: HF, EH, FK, ML and KS. Administrative, technical or material support: EH, MO and KS. Study supervision: EH and KS. All have contributed with writing, review and revision of the manuscript and have approved the final version of the paper.

  • Competing interests None.

  • Ethics approval Lund University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data have been uploaded to the European Nucleotide Archive. The study accession number is PRJEB8245. The study unique name is ena-STUDY-CHALMERS-19-01-2015-13:42:21:838-352. The study title is Metagenomic sequencing revealed altered microbiota in microscopic colitis.

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