Statistics from Altmetric.com
Recently, Shin et al1 reported that Akkermansia spp had a beneficial effect on glucose homeostasis in obese mice. Mucin degrading Akkermansia—promoting mucin degradation and turnover—is associated with a healthy mucosa. In IBD, a deranged microbiota is reported while findings in microscopic colitis (MC) are lacking. MC is a disorder characterised by chronic non-bloody diarrhoea, predominantly affecting elderly smoking women. Despite frequent diarrhoea, laboratory anomalies are seldom seen.
Since an altered microbiota is reported in several immune mediated diseases and since MC affects the gut, our hypothesis was that the microbiota would be altered in patients with MC.
A group of 10 female patients (mean age 48 years, range 43–68 years) with onset of MC collected as previously described2 donated faecal samples that were compared with samples from seven healthy control women (mean age 50 years, range 45–65 years) with respect to their faecal microbiota.
The bacterial microbiome was analysed by DNA sequencing (Illumina Hiseq 2000) and sequences were aligned to a …
Twitter Follow Måns Lindén at @mans_501
Contributors Conception and design: HF, EH, CB, ET, MO and KS. Development of methodology: HF and FK. Acquisition of data: HF, EH, CB, ET, MO, ML and KS. Analysis and interpretation of data: HF, EH, FK, ML and KS. Administrative, technical or material support: EH, MO and KS. Study supervision: EH and KS. All have contributed with writing, review and revision of the manuscript and have approved the final version of the paper.
Competing interests None.
Ethics approval Lund University.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement Data have been uploaded to the European Nucleotide Archive. The study accession number is PRJEB8245. The study unique name is ena-STUDY-CHALMERS-19-01-2015-13:42:21:838-352. The study title is Metagenomic sequencing revealed altered microbiota in microscopic colitis.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.