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Contributors AM and TS designed the project. AM, EN, SH, YK and KK performed the experiments. AM wrote the manuscript.
Funding This work was supported in part by the HIROMI Medical Research Foundation (to AM), by the Mother and Child Health Foundation (to AM), by the Smoking Research Foundation (to AM), by the Pancreas Research Foundation of Japan (to EN) and by the Ministry of Health, Labour and Welfare of Japan.
Competing interests None declared.
Patient consent Obtained.
Ethics approval The Ethics Committee of Tohoku University Graduate School of Medicine (article#: 2014-1-246 and 2014-1-681).
Provenance and peer review Not commissioned; internally peer reviewed.
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