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PWE-071 Interobserver agreement in assessment of rutgeerts' score of endoscopic recurrence of ileal crohn–s disease
  1. NA Kennedy1,
  2. H Ennis2,
  3. DR Gaya3,
  4. C Mowat4,
  5. IDR Arnott1,
  6. J Satsangi1
  7. On Behalf of TOPPIC Trial Investigators
  1. 1Gastrointestinal Unit, Western General Hospital
  2. 2Edinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh
  3. 3Gastrointestinal Unit, Glasgow Royal Infirmary, Glasgow
  4. 4Gastrointestinal Unit, Ninewells Hospital, Dundee, UK


Introduction Rutgeerts' score is widely used for the assessment of endoscopic recurrence following ileocaecal (IC) resection for Crohn–s disease (CD). Higher scores have been shown to be associated with an increased risk of clinical recurrence. TOPPIC is a double-blind randomised, placebo-controlled trial of mercaptopurine for the prevention of post-operative recurrence after IC resection for CD and includes a secondary endpoint of endoscopic recurrence. Few published data are available on interobserver agreement of Rutgeerts' score. This study aimed to assess the interobserver agreement of Rutgeerts' score on images from endoscopies carried out as part of the TOPPIC trial.

Method Five TOPPIC trial investigators were shown endoscopic images taken from 43 colonoscopies performed in Edinburgh as part of the TOPPIC trial. The investigators were blinded to the original report and were shown only the images with a description of the anatomical location from which each image was taken. Each investigator was independently asked to score each colonoscopy using the Rutgeerts' score and a custom-designed application. Statistical analysis was performed using R and the psych package. The five scores for each colonoscopy were compared with each other and the score made by the original endoscopist. Shrout and Fleiss' intraclass correlation and pairwise weighted Cohen–s kappa were calculated.

Results The original scores for the colonoscopies were spread across the possible scores, with 11 i0, 10 i1, 7 i2, 10 i3 and 5 i4. Intraclass correlation for single ratings (ICC3) was 0.82 (95% confidence interval 0.74–0.88). The weighted Cohen–s kappa when assessed for each possible pair of scorers ranged from 0.72 to 0.86. A graphical representation of the agreement between the original score and the rescores is shown in the Figure 1. When scores were stratified into endoscopic recurrence or not, as defined by a score of i2 or greater, all five scorers agreed with the original score in 34/43 (79%). There was no significant difference in this agreement between those procedures with an original score ≥i2 or

Conclusion Interobserver agreement for Rutgeerts' score of endoscopic recurrence was generally good in this cohort of patients. Despite the limitation of using still images, agreement with the score of the original endoscopistwas also good. However, there was some variation in assessment, even when assessing the presence/absence of endoscopic recurrence. These findings are important when considering the reliability of outcome data in multicentre clinical trials.

Disclosure of interest None Declared.

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