Article Text

Download PDFPDF

Original article
High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
  1. Francesca De Filippis1,
  2. Nicoletta Pellegrini2,
  3. Lucia Vannini3,4,
  4. Ian B Jeffery5,6,
  5. Antonietta La Storia1,
  6. Luca Laghi3,4,
  7. Diana I Serrazanetti4,
  8. Raffaella Di Cagno7,
  9. Ilario Ferrocino8,
  10. Camilla Lazzi2,
  11. Silvia Turroni9,
  12. Luca Cocolin8,
  13. Patrizia Brigidi9,
  14. Erasmo Neviani2,
  15. Marco Gobbetti7,
  16. Paul W O'Toole5,6,
  17. Danilo Ercolini1
  1. 1Department of Agricultural Sciences, Division of Microbiology, University of Naples Federico II, Via Università 100, Portici, Italy
  2. 2Department of Food Science, University of Parma, Parco Area delle Scienze 48/A, Parma, Italy
  3. 3Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, viale Fanin 44, Bologna, Italy
  4. 4Inter-Departmental Centre for Industrial Agri-Food Research, Alma Mater Studiorum University of Bologna, Piazza Goidanich 60 Cesena, Bologna, Italy
  5. 5Department of Microbiology, University College Cork, Cork, Ireland
  6. 6Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
  7. 7Department of Soil, Plant and Food Science, University of Bari Aldo Moro, Bari, Italy
  8. 8Department of Agricultural, Forest and Food Science, University of Turin, Grugliasco, Italy
  9. 9Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro, Bologna, Italy
  1. Correspondence to Professor Danilo Ercolini, Department of Agricultural Sciences, Division of Microbiology, University of Naples Federico II, Via Università 100, 80055 Portici, Italy; ercolini{at}unina.it

Footnotes

  • Contributors DE was responsible for the development of the study and preparation of the manuscript. DE, EN, LC, PB and MG contributed to the study design and coordinated the recruitment sites. RDC, IF, CL and ST recruited subjects and collected biospecimens. FDF and ALS performed the 16S rRNA gene sequencing. NP collected and analysed the dietary information. LV, LL and DIS performed the metabolome analysis. FDF and IBJ carried out the bioinformatics and statistical analyses and generated the manuscript figures. PWOT supervised the data analysis and contributed to manuscript preparation. MG is the project coordinator. All authors revised and approved the final version of the manuscript.

  • Funding This study was supported by the Italian Ministry of University and Research (MIUR) programme PRIN 2010–2011 (grant number 2010WZ2NJN). Work in PWOT's laboratory was supported by Science Foundation Ireland through a Centre award to the Alimentary Pharmabiotic Centre, and by an FP7 award to the NuAge project.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study was approved by the Ethics Committee of (a) Azienda Sanitaria Locale (Bari) (protocol N.1050), (b) Azienda Ospedaliera Universitaria of Bologna (protocol N.0018396), (c) Province of Parma (protocol N.22884) and (d) University of Torino (protocol N.1/2013/C).

  • Provenance and peer review Not commissioned; externally peer reviewed.

View Full Text

Statistics from Altmetric.com

Supplementary materials

  • Press release

    Files in this Data Supplement:

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

Footnotes

  • Contributors DE was responsible for the development of the study and preparation of the manuscript. DE, EN, LC, PB and MG contributed to the study design and coordinated the recruitment sites. RDC, IF, CL and ST recruited subjects and collected biospecimens. FDF and ALS performed the 16S rRNA gene sequencing. NP collected and analysed the dietary information. LV, LL and DIS performed the metabolome analysis. FDF and IBJ carried out the bioinformatics and statistical analyses and generated the manuscript figures. PWOT supervised the data analysis and contributed to manuscript preparation. MG is the project coordinator. All authors revised and approved the final version of the manuscript.

  • Funding This study was supported by the Italian Ministry of University and Research (MIUR) programme PRIN 2010–2011 (grant number 2010WZ2NJN). Work in PWOT's laboratory was supported by Science Foundation Ireland through a Centre award to the Alimentary Pharmabiotic Centre, and by an FP7 award to the NuAge project.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study was approved by the Ethics Committee of (a) Azienda Sanitaria Locale (Bari) (protocol N.1050), (b) Azienda Ospedaliera Universitaria of Bologna (protocol N.0018396), (c) Province of Parma (protocol N.22884) and (d) University of Torino (protocol N.1/2013/C).

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.