Article info

Original article
Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

Authors

  • Xavier Loyer INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Valérie Paradis Service d'Anatomie Pathologique, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France INSERM, U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Clichy, France Université Denis Diderot-Paris 7, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Carole Hénique INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Anne-Clémence Vion INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Nathalie Colnot Service d'Anatomie Pathologique, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France PubMed articlesGoogle scholar articles
  • Coralie L Guerin INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Cécile Devue INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Sissi On INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Jérémy Scetbun INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Mélissa Romain INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Jean-Louis Paul Service de Biochimie, Hôpital Européen Georges Pompidou, AP-HP (Assistance Publique-Hôpitaux de Paris), Paris, France PubMed articlesGoogle scholar articles
  • Marc E Rothenberg Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Patrick Marcellin INSERM, U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Clichy, France Université Denis Diderot-Paris 7, Sorbonne Paris Cité, Paris, France Service d'Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France PubMed articlesGoogle scholar articles
  • François Durand INSERM, U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Clichy, France Université Denis Diderot-Paris 7, Sorbonne Paris Cité, Paris, France Service d'Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France PubMed articlesGoogle scholar articles
  • Pierre Bedossa Service d'Anatomie Pathologique, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France INSERM, U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Clichy, France Université Denis Diderot-Paris 7, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Carina Prip-Buus Université Paris Descartes, Sorbonne Paris Cité, Paris, France INSERM, U1016, Institut Cochin, Paris, France CNRS, UMR8104, Paris, France PubMed articlesGoogle scholar articles
  • Eric Baugé Univ. Lille, Inserm, Institut Pasteur de Lille, U1011—EGID, Lille, France PubMed articlesGoogle scholar articles
  • Bart Staels Univ. Lille, Inserm, Institut Pasteur de Lille, U1011—EGID, Lille, France PubMed articlesGoogle scholar articles
  • Chantal M Boulanger INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Alain Tedgui INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France PubMed articlesGoogle scholar articles
  • Pierre-Emmanuel Rautou INSERM, U970, Paris Cardiovascular Research Center—PARCC, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France Université Denis Diderot-Paris 7, Sorbonne Paris Cité, Paris, France Service d'Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Pierre-Emmanuel Rautou, Paris—Centre de recherche Cardiovasculaire à l'HEGP, INSERM—U970, 56, rue Leblanc, 75373 Paris, cedex 15, France; pierre-emmanuel.rautou{at}inserm.fr
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Citation

Loyer X, Paradis V, Hénique C, et al
Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

Publication history

  • Received November 24, 2014
  • Revised August 9, 2015
  • Accepted August 13, 2015
  • First published September 3, 2015.
Online issue publication 
October 07, 2016

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