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High-dose vitamin D supplementation and liver histology in NASH
  1. Matthew T Kitson1,2,
  2. Alan Pham3,
  3. Adam Gordon1,2,
  4. William Kemp1,2,
  5. Stuart K Roberts1,2
  1. 1 Department of Gastroenterology, Alfred Hospital, Melbourne, Victoria, Australia
  2. 2 Department of Gastroenterology, Monash University, Melbourne, Victoria, Australia
  3. 3 Department of Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia
  1. Correspondence to Dr Matthew T Kitson, Department of Gastroenterology, The Alfred Hospital, 99 Commercial Rd, Melbourne, VIC 3004, Australia; m.kitson{at}alfred.org.au

https://doi.org/10.1136/gutjnl-2015-310417

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    Dear Editor,

    We read with great interest the recent study by Beilfuss et al,1 which found vitamin D supplementation to ameliorate transforming growth factor-β-induced fibrogenesis in human hepatic stellate cells.

    Vitamin D is an important secosteroid hormone with pleiotropic effects that extend well beyond its established regulatory role in calcium and bone homeostasis. These include its recently described involvement in the regulation of immunomodulation, cell proliferation and differentiation, as well as anti-inflammatory and anti-fibrotic properties.2 Subjects with non-alcoholic fatty liver disease (NAFLD) have a lower 25-hydroxyvitamin D [25(OH)D] level,3 which is …

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    Footnotes

    • Contributors MTK: Primary author, recruitment of patients, conceived and conducted study; AP: conducted histological analysis; AG and WK: recruitment of patients and SKR: co-author, supervisor of study, recruitment of patients.

    • Competing interests None declared.

    • Ethics approval Alfred Hospital Ethics Committee.

    • Provenance and peer review Not commissioned; internally peer reviewed.