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Contributors H-OA wrote the first draft of this manuscript and AE has resumed main responsibility for the literature review. Subsequently, all authors have been deeply involved in discussions and several rounds of editing of the manuscript to an extent that, beyond any doubt, justifies authorship. All authors have approved the current version.
Funding Karolinska Institutet Distinguished Professor Award to H-OA (Dnr: 2368/10-221), NIH grant P01 CA134294.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.