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Pancreas
Original article
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

Authors

  • Rajarshi Mukherjee NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Olga A Mareninova Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA PubMed articlesGoogle scholar articles
  • Irina V Odinokova Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia PubMed articlesGoogle scholar articles
  • Wei Huang NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK Department of Integrated Traditional and Western Medicine, Sichuan Provincial Pancreatitis Centre, West China Hospital, Sichuan University, Chengdu, People's Republic of China PubMed articlesGoogle scholar articles
  • John Murphy NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Michael Chvanov NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Muhammad A Javed NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Li Wen NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • David M Booth NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Matthew C Cane Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Muhammad Awais NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Bruno Gavillet Debiopharm Research and Manufacturing S.A., Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Rebecca M Pruss Trophos S.A., Marseille, France PubMed articlesGoogle scholar articles
  • Sophie Schaller Trophos S.A., Marseille, France PubMed articlesGoogle scholar articles
  • Jeffery D Molkentin Howard Hughes Medical Institute, Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Alexei V Tepikin NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Ole H Petersen Cardiff School of Biosciences, University of Cardiff, Cardiff, Wales, UK PubMed articlesGoogle scholar articles
  • Stephen J Pandol Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA PubMed articlesGoogle scholar articles
  • Ilya Gukovsky Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA PubMed articlesGoogle scholar articles
  • David N Criddle NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • Anna S Gukovskaya Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA PubMed articlesGoogle scholar articles
  • Robert Sutton NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Robert Sutton, NIHR Liverpool Pancreas Biomedical Research Unit, 5th Floor UCD, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK; r.sutton{at}liverpool.ac.uk Anna S. Gukovskaya, UCLA/Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Veterans Affairs Healthcare Center, 11301 Wilshire Blvd., Blg. 258, Rm. 340, Los Angeles, California 90073, USA; agukovsk{at}ucla.edu
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Citation

Mukherjee R, Mareninova OA, Odinokova IV and NIHR Pancreas Biomedical Research Unit, et al
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
Gut 2016;65:1333-1346.

Publication history

  • Received October 2, 2014
  • Revised March 16, 2015
  • Accepted April 7, 2015
  • First published June 12, 2015.
Online issue publication 
March 28, 2020

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/