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  • In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression

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Oesophagus
Original article
In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression

Authors

  • Kiyotaka Asanuma Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan PubMed articlesGoogle scholar articles
  • Xiaofang Huo Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Agoston Agoston Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Xi Zhang Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Chunhua Yu Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Edaire Cheng Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Department of Pediatrics, Children's Medical Center and the University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Qiuyang Zhang Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Kerry B Dunbar Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Thai H Pham Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Department of Surgery, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • David H Wang Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Katsunori Iijima Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan PubMed articlesGoogle scholar articles
  • Tooru Shimosegawa Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan PubMed articlesGoogle scholar articles
  • Robert D Odze Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Stuart J Spechler Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Rhonda F Souza Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA Departments of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Rhonda F Souza, Department of Gastroenterology, MC# 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA; rhonda.souza{at}utsouthwestern.edu
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Citation

Asanuma K, Huo X, Agoston A, et al
In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression
Gut 2016;65:1416-1426.

Publication history

  • Received January 28, 2015
  • Revised April 20, 2015
  • Accepted April 22, 2015
  • First published May 18, 2015.
Online issue publication 
November 07, 2016

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