Article Text

Download PDFPDF
Original article
Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis
  1. Sabine Klein1,
  2. Johanna Rick1,
  3. Jennifer Lehmann1,
  4. Robert Schierwagen1,
  5. Irela Gretchen Schierwagen2,
  6. Len Verbeke3,
  7. Kanishka Hittatiya4,
  8. Frank Erhard Uschner1,
  9. Steffen Manekeller5,
  10. Christian P Strassburg1,
  11. Kay-Uwe Wagner6,
  12. Peter P Sayeski7,
  13. Dominik Wolf8,
  14. Wim Laleman3,
  15. Tilman Sauerbruch1,
  16. Jonel Trebicka1
  1. 1Department of Internal Medicine I, University of Bonn, Bonn, Germany
  2. 2Institute for Cell Biology, University of Bonn, Bonn, Germany
  3. 3Department of Liver and Biliopancreatic Disorders, University of Leuven, Leuven, Belgium
  4. 4Institute of Pathology, University of Bonn, Bonn, Germany
  5. 5Department of General and Visceral Surgery, University of Bonn, Bonn, Germany
  6. 6Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
  7. 7Department of Physiology and Functional Genomics, University of Florida, College of Medicine, Gainesville, Florida, USA
  8. 8Medical Clinic III, Oncology, Hematology and Rheumatology, University of Bonn, Bonn, Germany
  1. Correspondence to Professor Dr Jonel Trebicka, Department of Internal Medicine I, University of Bonn, Sigmund-Freud Str. 25, Bonn D-53105, Germany; jonel.trebicka{at}ukb.uni-bonn.de

Footnotes

  • SK and JR contributed equally.

  • Contributors SK, JL, RS, IGS and WL: acquisition, analysis and interpretation of data, drafting of the manuscript. JR, LV, KH, FEU and DW: acquisition, analysis and interpretation of data. SM and K-UW: interpretation of data, administrative support. K-UW and PPS: interpretation of data, providing important animal models. TS: interpretation of data, drafting of the manuscript, obtaining funding, administrative support. JT: study concept and design, acquisition, analysis and interpretation of data, drafting of the manuscript, obtaining funding, administrative support, study supervision.

  • Funding The study was supported by grants from the Deutsche Forschungsgemeinschaft (SFB TRR57P18) and from H. J. & W. Hector Stiftung (M60.2).

  • Competing interests None declared.

  • Ethics approval Ethikkommision der Universität Bonn.

  • Provenance and peer review Not commissioned; externally peer reviewed.

View Full Text

Statistics from Altmetric.com

Footnotes

  • SK and JR contributed equally.

  • Contributors SK, JL, RS, IGS and WL: acquisition, analysis and interpretation of data, drafting of the manuscript. JR, LV, KH, FEU and DW: acquisition, analysis and interpretation of data. SM and K-UW: interpretation of data, administrative support. K-UW and PPS: interpretation of data, providing important animal models. TS: interpretation of data, drafting of the manuscript, obtaining funding, administrative support. JT: study concept and design, acquisition, analysis and interpretation of data, drafting of the manuscript, obtaining funding, administrative support, study supervision.

  • Funding The study was supported by grants from the Deutsche Forschungsgemeinschaft (SFB TRR57P18) and from H. J. & W. Hector Stiftung (M60.2).

  • Competing interests None declared.

  • Ethics approval Ethikkommision der Universität Bonn.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.