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Effects of enteral polymeric diet on gut microbiota in children with Crohn's disease
  1. Chloé Guinet-Charpentier1,
  2. Patricia Lepage2,
  3. Alain Morali1,
  4. Mathias Chamaillard3,
  5. Laurent Peyrin-Biroulet4
  1. 1Unité d'Hépato Gastro-Entérologie et Nutrition Pédiatriques, Service de Médecine Infantile et Génétique Clinique, Hôpital d'Enfants, Inserm U954, Université de Lorraine, Vandœuvre-lès-Nancy, France
  2. 2Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
  3. 3Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019—UMR 8204—CIIL—Centre d'Infection et d'Immunité de Lille, Lille, France
  4. 4Service d'Hépato-Gastro-Entérologie, Inserm U954, Université de Lorraine, Vandoeuvre-lès-Nancy, France
  1. Correspondence to Dr Chloé Guinet-Charpentier , Unité d'Hépato Gastro-Entérologie et Nutrition Pédiatriques, Service de Médecine Infantile et Génétique Clinique, Hôpital d'Enfants, CHU Nancy, Inserm U954, Université de Lorraine, Vandœuvre-lès-Nancy 54505, France; c.guinet{at}chu-nancy.fr

https://doi.org/10.1136/gutjnl-2015-311058

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    We read with great interest the article by Wu et al1 showing that the impact of diet on the composition of the gut microbiota was milder than its impact on metabolites produced by the gut microbiota, in healthy humans. Enteral nutrition is an effective treatment to manage active Crohn's disease (CD) in children.2 CD is known to be associated with gut microbial dysbiosis that is characterised by decreased diversity and imbalances in the intestinal microbiome. Recent evidence indicates that exclusive enteral nutrition (EEN) may affect gut microbiota in children with CD,3 but it remains elusive whether the aforementioned changes may occur independently of disease flares. We thus studied the impact of either EEN with Modulen (EXCL-MOD) or partial enteral nutrition (PEN) with Modulen (MOD) IBD on the bacterial composition of the gut microbiota from children with CD during either remission or active phase.

    In this single-centre, prospective, observational cohort study, 34 children followed at Nancy University Children Hospital …

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    Footnotes

    • Contributors CG-C, research, data collection, analysis of data, drafting of the manuscript; PL, analysis and interpretation of data, drafting of the manuscript; AM, data collection and drafting of the manuscript; MC, analysis and interpretation of data, drafting of the manuscript; LP-B, analysis of data, drafting of the manuscript and study supervision..

    • Funding National grant from Picot (Lactalis group).

    • Competing interests LP-B: Consulting fees from Merck, Abbvie, Janssen, Genentech, Mitsubishi, Ferring, Norgine, Tillots, Vifor, Therakos, Pharmacosmos, Pilège, BMS, UCB-pharma, Hospira, Celltrion, Takeda, Biogaran, Boerhinger-Ingelheim, Lilly, Pfizer, HAC-Pharma, Index Pharmaceuticals, Amgen, Sandoz, Forward Pharma GmbH, Celgene. Lecture fees from Merck, Abbvie, Takeda, Janssen, Takeda, Ferring, Norgine, Tillots, Vifor, Therakos, Mitsubishi, HAC-pharma.

    • Provenance and peer review Not commissioned; externally peer reviewed.