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Original article
hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation
  1. Changjiang Hu1,
  2. Zhenghong Ni2,
  3. Bo-sheng Li1,
  4. Xin Yong1,
  5. Xin Yang1,
  6. Jian-wei Zhang1,
  7. Dan Zhang1,
  8. Yong Qin1,
  9. Meng-meng Jie1,
  10. Hui Dong1,3,
  11. Song Li4,
  12. Fengtian He2,
  13. Shi-ming Yang1
  1. 1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
  2. 2Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China
  3. 3Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
  4. 4Department of Pharmaceutical Sciences, Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  1. Correspondence to Professor Shi-ming Yang, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; shimingyang{at}yahoo.com or Professor Fengtian He, Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China; hefengtian06{at}aliyun.com

Footnotes

  • Contributors CH performed most of the experiments, analysed the data and drafted the manuscript. ZN performed the GST pull-down experiments and helped draft the manuscript. B-sL, XYo and XYa took part in qRT-PCR and western blot analysis. J-wZ and DZ contributed to statistical analysis. YQ and M-mJ participated in the collection of gastric cancer tissues and the corresponding adjacent non-cancerous tissues. HD and SL contributed to polish the manuscript. FH and S-mY conceived the study, participated in its design and coordination, supervised the experiments and drafted the manuscript. All authors read and approved the final manuscript.

  • Funding This work was supported by the National Natural Science Foundation of China (No. 81402034).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Third Military Medical University Medical Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors CH performed most of the experiments, analysed the data and drafted the manuscript. ZN performed the GST pull-down experiments and helped draft the manuscript. B-sL, XYo and XYa took part in qRT-PCR and western blot analysis. J-wZ and DZ contributed to statistical analysis. YQ and M-mJ participated in the collection of gastric cancer tissues and the corresponding adjacent non-cancerous tissues. HD and SL contributed to polish the manuscript. FH and S-mY conceived the study, participated in its design and coordination, supervised the experiments and drafted the manuscript. All authors read and approved the final manuscript.

  • Funding This work was supported by the National Natural Science Foundation of China (No. 81402034).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Third Military Medical University Medical Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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