A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD

Han Sang Kim; Jae Hee Cheon; Eun Suk Jung; Joonhee Park; Sowon Aum; Soo Jung Park; Sungho Eun; Jinu Lee; Ulrich Rüther; Giles S H Yeo; Marcella Ma; Kyong Soo Park; Takeo Naito; Yoichi Kakuta; Ji Hyun Lee; Won Ho Kim; Min Goo Lee

doi:10.1136/gutjnl-2016-311921

Article info

Inflammatory bowel disease

Original article

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD

Authors

Han Sang Kim Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Jae Hee Cheon Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Eun Suk Jung Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Joonhee Park Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Sowon Aum Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Soo Jung Park Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Sungho Eun Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Jinu Lee College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Inchon, Korea PubMed articles Google scholar articles
Ulrich Rüther Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, Düsseldorf, Germany PubMed articles Google scholar articles
Giles S H Yeo University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK PubMed articles Google scholar articles
Marcella Ma University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK PubMed articles Google scholar articles
Kyong Soo Park Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Takeo Naito Division of Gastroenterology, Tohoku University Hospital, Miyagi, Japan PubMed articles Google scholar articles
Yoichi Kakuta Division of Gastroenterology, Tohoku University Hospital, Miyagi, Japan PubMed articles Google scholar articles
Ji Hyun Lee Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul, Korea PubMed articles Google scholar articles
Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles
Min Goo Lee Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea PubMed articles Google scholar articles

Correspondence to Dr Min Goo Lee, Department of Pharmacology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seoul 120-752, Korea; mlee{at}yuhs.ac and Dr Won Ho Kim, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, Korea; KIMWONHO{at}yuhs.ac

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Citation

Kim HS, Cheon JH, Jung ES, et al

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD

Gut 2017;66:1926-1935.

Publication history

Received March 24, 2016
Revised July 21, 2016
Accepted July 26, 2016
First published August 24, 2016.

Online issue publication

December 13, 2017

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