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Activation of protease-activated receptor 4 of mast cells could downregulate proinflammatory cytokines in irritable bowel syndrome

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  • Contributors ZW, SA and JH designed the overall project. GZ and JH were responsible for acquisition of data. SA, JS and HD performed in vitro experiments. ZW, SA and GZ were responsible for the analysis and interpretation of the data, and drafted the manuscript. All authors revised and approved the final manuscript.

  • Funding The study was supported by National Natural Science Foundation of China (No. 81371234) and Natural Science Foundation of Shandong Province, China (ZR2013HM032).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The Ethics Committee of the Taishan Medical University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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