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In vitro and in silico evidence against a significant effect of the SPINK1 c.194G>A variant on pre-mRNA splicing

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  • Contributors J-MC, ZL, Z-SL and CF designed and directed the study. HW and AB performed functional analysis. J-MC drafted the manuscript. DNC critically revised the manuscript. All authors analysed the data and approved the final manuscript.

  • Funding HW is a joint PhD student between the Changhai Hospital and INSERM U1078 who was in receipt of a 1-year scholarship from the China Scholarship Council (No. 201503170355). Support for this study came from the National Natural Science Foundation of China (Grant Nos. 81470884 and 81422010; to ZL), the Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (Grant No. 15SG33; to ZL), the Chang Jiang Scholars Program of Ministry of Education, People's Republic of China (Grant No. Q2015190; to ZL); the Conseil Régional de Bretagne, the Association des Pancréatites Chroniques Héréditaires, the Association de Transfusion Sanguine et de Biogénétique Gaetan Saleun, the Institut National de la Santé et de la Recherche Médicale (INSERM), France.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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