Footnotes

• Twitter Follow Pablo Olivera at @poliverasendra

• Contributors PO and LP-B wrote the article. PO drafted all figures. SD critically reviewed the article for intellectual content.

• Competing interests PO declares no conflict of interest. SD has served as a speaker, a consultant and an advisory board member for Abbvie, Ferring, Hospira, Johnson & Johnson, Merck, Millennium Takeda, Mundipharma, Pfizer Inc, Tigenix, UCB Pharma, and Vifor. LP-B: consulting fees from Merck, Abbvie, Janssen, Genentech, Mitsubishi, Ferring, Norgine, Tillots, Vifor, Therakos, Pharmacosmos, Pilège, BMS, UCB-pharma, Hospira, Celltrion, Takeda, Biogaran, Boerhinger-Ingelheim, Lilly, Pfizer, HAC-Pharma, Index Pharmaceuticals, Amgen, Sandoz. Lecture fees from Merck, Abbvie, Takeda, Janssen, Ferring, Norgine, Tillots, Vifor, Therakos, Mitsubishi, HAC-pharma.

• Provenance and peer review Commissioned; externally peer reviewed.