You are here

  • Home
  • Archive
  • Volume 66, Issue 2
  • Reply to the letter by Dr Graham concerning ethical and interpretation issues with vonoprazan-containing H. pylori eradication therapy

Article Text

Article menu
Download PDFPDF
PostScript
Letter
Reply to the letter by Dr Graham concerning ethical and interpretation issues with vonoprazan-containing H. pylori eradication therapy
  1. Kazunari Murakami1,
  2. Yuuichi Sakurai2,
  3. Madoka Shiino2,
  4. Nobuo Funao2,
  5. Akira Nishimura2,
  6. Masahiro Asaka3
  1. 1 Department of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan
  2. 2 Takeda Pharmaceutical Company Ltd., Osaka, Japan
  3. 3 Health Sciences University of Hokkaido, Hokkaido, Japan
  1. Correspondence to Professor Masahiro Asaka, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, Hokkaido 061-0293, Japan; maasaka{at}hoku-iryo-u.ac.jp

http://dx.doi.org/10.1136/gutjnl-2016-312011

Statistics from Altmetric.com

    We thank Dr Graham for his interest in our article.1 ,2 In Japan, 7 days administration of PPI+amoxicillin+clarithromycin is standard treatment for Helicobacter pylori eradication3 and is the only approved treatment as first-line therapy in Japan. Therefore, there is no ethical issue in increasing sample size to match the current eradication rate. In a blinded interim analysis, the overall eradication rate was 81.6%, which was a lower rate than 90% that …

    View Full Text

    Footnotes

    • Contributors KM, YS, MS, NF, AN and MA wrote and approved the author's response to the Letter by Dr Graham.

    • Competing interests KM and MA are independent medical consultants providing expert advice to Takeda Pharmaceutical Company Ltd. YS, MS, NF and AN are employees of Takeda Pharmaceutical Company Ltd.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Copyright information:

    Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

    Linked Articles