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We thank Dr Graham for his interest in our article.1 ,2 In Japan, 7 days administration of PPI+amoxicillin+clarithromycin is standard treatment for Helicobacter pylori eradication3 and is the only approved treatment as first-line therapy in Japan. Therefore, there is no ethical issue in increasing sample size to match the current eradication rate. In a blinded interim analysis, the overall eradication rate was 81.6%, which was a lower rate than 90% that …
Contributors KM, YS, MS, NF, AN and MA wrote and approved the author's response to the Letter by Dr Graham.
Competing interests KM and MA are independent medical consultants providing expert advice to Takeda Pharmaceutical Company Ltd. YS, MS, NF and AN are employees of Takeda Pharmaceutical Company Ltd.
Provenance and peer review Not commissioned; internally peer reviewed.
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