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  • The reduced chance of a live birth in women with IBD receiving assisted reproduction is due to a failure to achieve a clinical pregnancy

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The reduced chance of a live birth in women with IBD receiving assisted reproduction is due to a failure to achieve a clinical pregnancy
  1. S Friedman1,2,3,
  2. P V Larsen1,
  3. J Fedder4,
  4. B M Nørgård1,2,3
  1. 1Center for Clinical Epidemiology, Odense University Hospital, and Research Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
  2. 2Crohn's and Colitis Center, Brigham and Women's Hospital, Boston, Massachusetts, USA
  3. 3Department of Medicine, Division of Gastroenterology, Hepatology and Endoscopy, Harvard Medical School, Boston, Massachusetts, USA
  4. 4Department D, Centre of Andrology and Fertility Clinic, Odense University Hospital, and Research Unit of Human Reproduction, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
  1. Correspondence to Dr Sonia Friedman, Center for Crohn's and Colitis, 850 Boylston Street, Chestnut Hill, MA 02467, USA; sfriedman1{at}partners.org

https://doi.org/10.1136/gutjnl-2016-311805

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    We recently reported that for women with UC receiving assisted reproductive technology (ART) treatment, the chance of a live birth after each embryo transfer cycle decreased significantly. In women with Crohn's disease (CD), the chance of a live birth after each embryo transfer cycle also decreased but was not significant in the fully adjusted regression model.1 In our study, we chose the outcome live birth because it was the most important clinical outcome for patients with UC and CD undergoing ART. After demonstrating the negative effects of UC and CD on chances of live birth, we wish to update our readers by exploring where along the process from fertilisation through pregnancy the risk of delivering a live born child decreases. Is the reduced chance of live birth due to (1) a reduced chance of conceiving after an ART cycle? and/or (2) a reduced chance of maintaining a fetus …

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    Footnotes

    • Contributors SF: funding, conception, interpretation of results, manuscript writing and editing, approved the final version. PVL: design, data collection, data analysis, interpretation of results, manuscript editing, approved the final version. JF: assistance with data analysis, interpretation of results, manuscript editing, approved the final version. BMN: funding, conception, design, data collection, assistance with data analysis, interpretation of results, manuscript writing and editing, approved the final version.

    • Funding The study was supported by a Crohn's & Colitis Foundation of America (CCFA), Senior Research Award.

    • Competing interests None declared.

    • Ethics approval The study was approved by the Danish Data Protection Agency (j.nr. 2014-41-3466). According to Danish law, there are no ethical approvals of register-based studies necessary.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • ▸ Additional material is published online only. To view, please visit the journal online (http://dx.doi.org/10.1136/gutjnl-2016-311805).