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Contributors CJ, CB and JT wrote the letter and performed calculation, SF and AK approved and critically discussed the letter.
Funding This study was supported by grants from the Deutsche Forschungsgemeinschaft (SFB TRR57 to P18), the H. J. & W. Hector Stiftung, Ernst-Bertha-Grimmke-Stiftung (6/15) and European Union's Horizon 2020 research and innovation programme (No 668031).
Competing interests None declared.
Patient consent Obtained.
Ethics approval University of Bonn.
Provenance and peer review Not commissioned; internally peer reviewed.