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We read with great interest the elegant work of Sayed et al,1 which established a mouse model for chronic hepatitis E virus (HEV) infections. The study showed that mice with humanised livers could be infected with both HEV-1 and HEV-3 and develop a chronic viral infection. The establishment of this model meets the urgent need for a research animal model to study chronic hepatitis E infection as increasing cases of such infections have been reported in immunocompromised patients.2 We have recently reported on a chronic hepatitis E case caused by HEV-4 in a woman with nephritic syndrome.3 HEV RNA and antigen were detected in the patient's urine and HEV RNA-positive urine successfully induced infection in Cynomolgus monkeys.3 We agree with the claim made by Sayed et al1 that their model may allow the unravelling of the potential relationship between HEV infection and kidney disease. However, this will require …
Contributors LingW designed the experiment. LinW and JX performed the experiment and analysed the data. LinW, LingW and YW wrote the manuscript. All authors have read and approved the manuscript.
Funding This work was supported by the National Science Foundation of China (grant number 81271827) and the Beijing Natural Science Foundation (grant number 7162103).
Competing interests None declared.
Ethics approval Committee of Laboratory Animal Welfare and Ethics, Peking University Health Science Center.
Provenance and peer review Not commissioned; internally peer reviewed.
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