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  • ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1

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Original article
ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1

Authors

  • Oriol de Barrios Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Balázs Győrffy Lendület Cancer Biomarker Research Group, MTA TTK and 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary PubMed articlesGoogle scholar articles
  • María Jesús Fernández-Aceñero Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain Department of Pathology, Hospital Clínico San Carlos, Madrid, Spain PubMed articlesGoogle scholar articles
  • Ester Sánchez-Tilló Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Lidia Sánchez-Moral Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Laura Siles Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Anna Esteve-Arenys Lymphoma Group, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Gaël Roué Lymphoma Group, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain PubMed articlesGoogle scholar articles
  • José I Casal Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain PubMed articlesGoogle scholar articles
  • Douglas S Darling Department of Oral Immunology and Infectious Diseases and Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, USA PubMed articlesGoogle scholar articles
  • Antoni Castells Institute of Metabolic and Digestive Diseases, Hospital Clínic, Barcelona, Spain Gastrointestinal and Pancreatic Oncology Team, Biomedical Research Networking Centers in Hepatic and Digestive Diseases (CIBERehd), Carlos III Health Institute (ISCIII), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Antonio Postigo Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain Gastrointestinal and Pancreatic Oncology Team, Biomedical Research Networking Centers in Hepatic and Digestive Diseases (CIBERehd), Carlos III Health Institute (ISCIII), Barcelona, Spain Molecular Targets Program, James Graham Brown Cancer Center, Louisville, Kentucky, USA ICREA, Barcelona, Spain PubMed articlesGoogle scholar articles
  1. Correspondence to DR A Postigo, Group of Transcriptional Regulation of Gene Expression, IDIBAPS, Casanova 143, Barcelona 08036, Spain; idib412{at}clinic.cat
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Citation

de Barrios O, Győrffy B, Fernández-Aceñero MJ, et al
ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
Gut 2017;66:666-682.

Publication history

  • Received October 5, 2015
  • Revised September 16, 2016
  • Accepted October 5, 2016
  • First published December 13, 2016.
Online issue publication 
May 24, 2017

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