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MCR and F-AH contributed equally.
AF and CS jointly supervised.
Contributors AF and CS designed the study. CS, RZ and WL provided patient data and material. MCR, F-AH and AF analysed the data. AF, CS, MCR and F-AH wrote the manuscript. All authors have read and approved the final version.
Funding This work was supported by the Deutsche Forschungsgemeinschaft (DFG), KFO306 and Cluster of Excellence ‘Inflammation at Interfaces’, the biobank popgen (the popgen 2.0 network is financed by the German Ministry of Education and Research (grant 01EY1103)) and the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding program (SysInflame grant 01ZX1306A).
Competing interests None declared.
Ethics approval Ethics committees of University of Kiel and University of Hamburg.
Provenance and peer review Not commissioned; internally peer reviewed.
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