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  • Response to ‘Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis’ by Rühlemann et al

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Letter
Response to ‘Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis’ by Rühlemann et al
  1. Martin Kummen,
  2. Johannes R Hov
  1. Department of Transplantation Medicine, Norwegian PSC Research Center and Institute of Clinical Medicine, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
  1. Correspondence to Dr Martin Kummen, Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, P. O. Box 4950, Nydalen, Oslo 0424, Norway; martin.kummen{at}medisin.uio.no

https://doi.org/10.1136/gutjnl-2016-312347

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    We read with great interest and enthusiasm the letter from Rühlemann et al1 regarding the possible diagnostic role of the faecal microbial profile in primary sclerosing cholangitis (PSC). In the study, 73 well-characterised patients with PSC were compared with 98 healthy control (HC) subjects and 88 subjects with UC in order to validate a diagnostic panel of microbial markers identified in our recent study of PSC.2

    Out of 12 taxa included in a diagnostic panel, 10 were also identified in the German dataset. Using these 10 taxa, Rühlemann et al obtained the area under the curves (AUCs) of 0.86 and 0.79 for discriminating HC from PSC, and UC from PSC, respectively, validating …

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    Footnotes

    • Contributors MK and JRH drafted the letter.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.