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We read with interest the commentary of Raes1 on the growing clinical role of microbiome-based companion diagnostics. We agree that the future of microbiome in medical practice will be in using markers for diagnosis as well as predicting and personalising treatment. We report here new observations on a colonic bacteria that, while traditionally considered a commensal, may be important in chronic diarrhoea and IBS.
Colonisation of the colon by Brachyspira aalborgi and B. pilosicoli is characterised by the histological finding of extensive, densely packed, end-on attachment of spirochaetes to the mucosal wall, which is visible on H&E stain as a hazy mucosal border; bacterial colonisation is dramatically demonstrated by Warthin-Starry staining like Helicobacter pylori (figure 1).2 ,3 The significance of this finding and its role in human disease has been debated in the literature and generally colonic spirochaetosis (CS) is considered to be a …
Contributors TMG, NJT, MMW, AZ and NKW contributed to the conception and design of the study. TMG, AZ, MMW, LR and NKW were responsible for acquisition of data. TMG, MJ and NJT were responsible for the analysis and interpretation of the data. All authors were responsible for drafting, critical revision and final approval of the article.
Competing interests None declared.
Ethics approval Hunter New England Human Research Ethics Committee.
Provenance and peer review Not commissioned; internally peer reviewed.
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