Gut: 66 (9)

Commentaries

Novel insight in diarrhoea-predominant IBS: miRNAs modulate barrier function (9 August, 2017)
Mira M Wouters
Challenges in the hepatic histopathology in non-alcoholic fatty liver disease (9 August, 2017)
Elizabeth M Brunt, David E Kleiner
Selective LOXL2 inhibition: potent antifibrotic effects in ongoing fibrosis and fibrosis regression (9 August, 2017)
Fernando Magdaleno, Jonel Trebicka

Oesophagus

Original article: Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD (9 August, 2017)
Xiaofang Huo, Agoston T Agoston, Kerry B Dunbar, Daisha J Cipher, Xi Zhang, Chunhua Yu, Edaire Cheng, Qiuyang Zhang, Thai H Pham, Uttam K Tambar, Richard K Bruick, David H Wang, Robert D Odze, Stuart J Spechler, Rhonda F Souza

Stomach

Original article: The gastric acid pocket is attenuated in H. pylori infected subjects (9 August, 2017)
David R Mitchell, Mohammad H Derakhshan, Angela A Wirz, Clare Orange, Stuart A Ballantyne, James J Going, Kenneth E L McColl

Coeliac disease

Original article: The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000–2015) (9 August, 2017)
Imran Aziz, Mohammad F Peerally, Jodie-Hannah Barnes, Vigneswaran Kandasamy, Jack C Whiteley, David Partridge, Patricia Vergani, Simon S Cross, Peter H Green, David S Sanders

Inflammatory bowel disease

Original article: Proteomic analysis of ascending colon biopsies from a paediatric inflammatory bowel disease inception cohort identifies protein biomarkers that differentiate Crohn's disease from UC (9 August, 2017)
Amanda E Starr, Shelley A Deeke, Zhibin Ning, Cheng-Kang Chiang, Xu Zhang, Walid Mottawea, Ruth Singleton, Eric I Benchimol, Ming Wen, David R Mack, Alain Stintzi, Daniel Figeys

Experimental colitis

Original article: The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1 (9 August, 2017)
Samuel Bertin, Yukari Aoki-Nonaka, Jihyung Lee, Petrus R de Jong, Peter Kim, Tiffany Han, Timothy Yu, Keith To, Naoki Takahashi, Brigid S Boland, John T Chang, Samuel B Ho, Scott Herdman, Maripat Corr, Alessandra Franco, Sonia Sharma, Hui Dong, Armen N Akopian, Eyal Raz

Neurogastroenterology

Original article: miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea (9 August, 2017)
Cristina Martínez, Bruno K Rodiño-Janeiro, Beatriz Lobo, Megan L Stanifer, Bernd Klaus, Martin Granzow, Ana M González-Castro, Eloisa Salvo-Romero, Carmen Alonso-Cotoner, Marc Pigrau, Ralph Roeth, Gudrun Rappold, Wolfgang Huber, Rosa González-Silos, Justo Lorenzo, Inés de Torres, Fernando Azpiroz, Steeve Boulant, María Vicario, Beate Niesler, Javier Santos
Original article: Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis (9 August, 2017)
Alfred D Nelson, Michael Camilleri, Sakkarin Chirapongsathorn, Priya Vijayvargiya, Nelson Valentin, Andrea Shin, Patricia J Erwin, Zhen Wang, M Hassan Murad

Gut microbiota

Original Article: Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study (9 August, 2017)
Jacqueline M Lankelma, Duncan R Cranendonk, Clara Belzer, Alex F de Vos, Willem M de Vos, Tom van der Poll, W Joost Wiersinga

Colon

Original article: Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England (9 August, 2017)
Sue Moss, Christopher Mathews, T J Day, Steve Smith, Helen E Seaman, Julia Snowball, Stephen P Halloran
Original article: RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation (9 August, 2017)
Helen H N Yan, Jeffrey C W Lai, Siu Lun Ho, Wai Keung Leung, Wai Lun Law, Janet F Y Lee, Anthony K W Chan, Wai Yin Tsui, Annie S Y Chan, Bernard C H Lee, Sarah S K Yue, Alice H Y Man, Hans Clevers, Siu Tsan Yuen, Suet Yi Leung
Original article: Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database (9 August, 2017)
Pål Møller, Toni Seppälä, Inge Bernstein, Elke Holinski-Feder, Paola Sala, D Gareth Evans, Annika Lindblom, Finlay Macrae, Ignacio Blanco, Rolf Sijmons, Jacqueline Jeffries, Hans Vasen, John Burn, Sigve Nakken, Eivind Hovig, Einar Andreas Rødland, Kukatharmini Tharmaratnam, Wouter H de Vos tot Nederveen Cappel, James Hill, Juul Wijnen, Mark Jenkins, Kate Green, Fiona Lalloo, Lone Sunde, Miriam Mints, Lucio Bertario, Marta Pineda, Matilde Navarro, Monika Morak, Laura Renkonen-Sinisalo, Ian M Frayling, John-Paul Plazzer, Kirsi Pylvanainen, Maurizio Genuardi, Jukka-Pekka Mecklin, Gabriela Möslein, Julian R Sampson, Gabriel Capella, in collaboration with The Mallorca Group (http://mallorca-group.org)

Pancreas

Original article: GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer (9 August, 2017)
Paola Martinelli, Enrique Carrillo-de Santa Pau, Trevor Cox, Bruno Sainz, Nelson Dusetti, William Greenhalf, Lorenzo Rinaldi, Eithne Costello, Paula Ghaneh, Núria Malats, Markus Büchler, Marina Pajic, Andrew V Biankin, Juan Iovanna, John Neoptolemos, Francisco X Real
Original article: Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms (9 August, 2017)
Jun Yu, Yoshihiko Sadakari, Koji Shindo, Masaya Suenaga, Aaron Brant, Jose Alejandro Navarro Almario, Michael Borges, Thomas Barkley, Shahriar Fesharakizadeh, Madeline Ford, Ralph H Hruban, Eun Ji Shin, Anne Marie Lennon, Marcia Irene Canto, Michael Goggins

Hepatology

Original article: Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity (9 August, 2017)
Pierre Bedossa, Joan Tordjman, Judith Aron-Wisnewsky, Christine Poitou, Jean-Michel Oppert, Adriana Torcivia, Jean-Luc Bouillot, Valerie Paradis, Vlad Ratziu, Karine Clément
Original article: Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal (9 August, 2017)
Naoki Ikenaga, Zhen-Wei Peng, Kahini A Vaid, Susan B Liu, Shuhei Yoshida, Deanna Y Sverdlov, Amanda Mikels-Vigdal, Victoria Smith, Detlef Schuppan, Yury V Popov

Recent advances in clinical practice

Feeding the microbiota: transducer of nutrient signals for the host (9 August, 2017) Free
Fergus Shanahan, Douwe van Sinderen, Paul W O’Toole, Catherine Stanton

JournalScan

GI highlights from the literature (9 August, 2017)
Mairi H McLean

PostScript

Letter: High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study (9 August, 2017)
Masahiro Maeda, Takeshi Nakajima, Ichiro Oda, Taichi Shimazu, Nobutake Yamamichi, Takao Maekita, Kiyoshi Asada, Chizu Yokoi, Takayuki Ando, Takeichi Yoshida, Sohachi Nanjo, Mitsuhiro Fujishiro, Takuji Gotoda, Masao Ichinose, Toshikazu Ushijima
Letter: Influence of potassium-competitive acid blocker on the gut microbiome of Helicobacter pylori-negative healthy individuals (9 August, 2017)
Taketo Otsuka, Mitsushige Sugimoto, Ryo Inoue, Masashi Ohno, Hiromitsu Ban, Atsushi Nishida, Osamu Inatomi, Shunsuke Takahashi, Yuji Naito, Akira Andoh
Letter: TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M (9 August, 2017)
Maria Henström, Fatemeh Hadizadeh, Arthur Beyder, Ferdinando Bonfiglio, Tenghao Zheng, Ghazaleh Assadi, Joseph Rafter, Luis Bujanda, Lars Agreus, Anna Andreasson, Aldona Dlugosz, Greger Lindberg, Peter T Schmidt, Pontus Karling, Bodil Ohlsson, Nicholas J Talley, Magnus Simren, Susanna Walter, Mira Wouters, Gianrico Farrugia, Mauro D'Amato
Letter: Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis (9 August, 2017)
Balázs Csaba Németh, Árpád V Patai, Miklós Sahin-Tóth, Péter Hegyi
Letter: A novel p.Ser282Pro CPA1 variant is associated with autosomal dominant hereditary pancreatitis (9 August, 2017)
Aleksandra A Kujko, Dorottya M. Berki, Grzegorz Oracz, Karolina Wejnarska, Justyna Antoniuk, Katarzyna Wertheim-Tysarowska, Elwira Kołodziejczyk, Jerzy Bal, Miklós Sahin-Tóth, Agnieszka M Rygiel

Editor’s quiz: GI snapshot

When radiology meets gastroenterology: an unusual impact (9 August, 2017)
Grigoriy E Gurvits

Correction

Correction: Erratum: The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B (9 August, 2017)

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Table of contents

September 2017 - Volume 66 - 9

Commentaries

Oesophagus

Stomach

Coeliac disease

Inflammatory bowel disease

Experimental colitis

Neurogastroenterology

Gut microbiota

Colon

Pancreas

Hepatology

Recent advances in clinical practice

JournalScan

PostScript

Editor’s quiz: GI snapshot

Correction

Issue Information

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Table of contents

September 2017 - Volume 66 - 9

Commentaries

Oesophagus

Stomach

Coeliac disease

Inflammatory bowel disease

Experimental colitis

Neurogastroenterology

Gut microbiota

Colon

Pancreas

Hepatology

Recent advances in clinical practice

JournalScan

PostScript

Editor’s quiz: GI snapshot

Correction

Issue Information