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  • miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea

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Neurogastroenterology
Original article
miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea

Authors

  • Cristina Martínez Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Bruno K Rodiño-Janeiro Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Beatriz Lobo Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Megan L Stanifer Schaller Research Group at CellNetworks, Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Bernd Klaus European Molecular Biology Laboratory (EMBL), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Martin Granzow Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Ana M González-Castro Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Eloisa Salvo-Romero Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Carmen Alonso-Cotoner Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network PubMed articlesGoogle scholar articles
  • Marc Pigrau Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Ralph Roeth Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany nCounter Core Facility, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Gudrun Rappold Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Wolfgang Huber European Molecular Biology Laboratory (EMBL), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Rosa González-Silos Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Justo Lorenzo Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Inés de Torres Department of Pathology, Facultat de Medicina, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Fernando Azpiroz Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network PubMed articlesGoogle scholar articles
  • Steeve Boulant Schaller Research Group at CellNetworks, Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany Research Group ‘Cellular Polarity and Viral Infection’ (F140), German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • María Vicario Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network PubMed articlesGoogle scholar articles
  • Beate Niesler Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network nCounter Core Facility, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Javier Santos Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Barcelona, Spain Facultat de Medicina, Department of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Cristina Martinez, Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Department of Gastroenterology, Vall d'Hebron Institut de Recerca, Hospital Universitario Vall d'Hebron, Paseo Vall d'Hebron 119-129, Barcelona 08035, Spain; cristina.martinez{at}med.uni-heidelberg.de, cristina.martinez{at}vhir.org Prof Javier Santos Vicente, Laboratory of Neuro-immuno-gastroenterology, Digestive System Research Unit, Vall d’Hebron Institut de Recerca, Department of Gastroenterology, Hospital Universitario Vall d'Hebron. Paseo Vall d’ Hebron 119-129, Barcelona, Spain; javier.santos{at}vhir.org
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Citation

Martínez C, Rodiño-Janeiro BK, Lobo B, et al
miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea
Gut 2017;66:1537-1538.

Publication history

  • Received January 19, 2016
  • Revised November 29, 2016
  • Accepted November 30, 2016
  • First published January 12, 2017.
Online issue publication 
December 06, 2017

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/