Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

Pål Møller; Toni Seppälä; Inge Bernstein; Elke Holinski-Feder; Paola Sala; D Gareth Evans; Annika Lindblom; Finlay Macrae; Ignacio Blanco; Rolf Sijmons; Jacqueline Jeffries; Hans Vasen; John Burn; Sigve Nakken; Eivind Hovig; Einar Andreas Rødland; Kukatharmini Tharmaratnam; Wouter H de Vos tot Nederveen Cappel; James Hill; Juul Wijnen; Mark Jenkins; Kate Green; Fiona Lalloo; Lone Sunde; Miriam Mints; Lucio Bertario; Marta Pineda; Matilde Navarro; Monika Morak; Laura Renkonen-Sinisalo; Ian M Frayling; John-Paul Plazzer; Kirsi Pylvanainen; Maurizio Genuardi; Jukka-Pekka Mecklin; Gabriela Möslein; Julian R Sampson; Gabriel Capella; in collaboration with The Mallorca Group (http://mallorca-group.org)

doi:10.1136/gutjnl-2016-311403

Article info

PDF

PDF +
Supplementary
Material

XML

Colon

Original article

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

Authors

Pål Møller Research Group Inherited Cancer, Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Part of Oslo University Hospital, Oslo, Norway Surgical Center for Hereditary Tumors, HELIOS University Clinic Wuppertal, University Witten-Herdecke, Wuppertal, Germany PubMed articles Google scholar articles
Toni Seppälä Department of Surgery, Central Finland Health Care District, Jyväskylä, Finland PubMed articles Google scholar articles
Inge Bernstein The Danish Hereditary Non-polyposis Colorectal Cancer Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark Department Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark PubMed articles Google scholar articles
Elke Holinski-Feder Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany MGZ—Medizinisch Genetisches Zentrum, Munich, Germany PubMed articles Google scholar articles
Paola Sala Unit of Hereditary Digestive Tract Tumors IRCCS, Istituto Nazionale Tumori, Milan, Italy PubMed articles Google scholar articles
D Gareth Evans Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Annika Lindblom Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Finlay Macrae Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Victoria, Australia Department of Medicine, Melbourne University, Melbourne, Australia PubMed articles Google scholar articles
Ignacio Blanco Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articles Google scholar articles
Rolf Sijmons Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articles Google scholar articles
Jacqueline Jeffries Institute of Medical Genetics, Cardiff University School of Medicine, Cardiff, UK PubMed articles Google scholar articles
Hans Vasen Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands PubMed articles Google scholar articles
John Burn Institute of Genetic Medicine Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Sigve Nakken Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Part of Oslo University Hospital, Oslo, Norway PubMed articles Google scholar articles
Eivind Hovig Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Part of Oslo University Hospital, Oslo, Norway Institute of Cancer Genetics and Informatics, The Norwegian Radium Hospital, Part of Oslo University Hospital, Oslo, Norway Department of Informatics, University of Oslo, Oslo, Norway PubMed articles Google scholar articles
Einar Andreas Rødland Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Part of Oslo University Hospital, Oslo, Norway PubMed articles Google scholar articles
Kukatharmini Tharmaratnam Department of Mathematics and Statistics, Lancaster University, Lancaster, UK PubMed articles Google scholar articles
Wouter H de Vos tot Nederveen Cappel Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands PubMed articles Google scholar articles
James Hill Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK PubMed articles Google scholar articles
Juul Wijnen Department of Clinical Genetics and Department of Human Genetics Leiden University Medical Centre, Leiden, The Netherlands PubMed articles Google scholar articles
Mark Jenkins Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia PubMed articles Google scholar articles
Kate Green Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Fiona Lalloo Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Lone Sunde The Danish Hereditary Non-polyposis Colorectal Cancer Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark Department of Biomedicine, Aarhus University, Aarhus, Denmark PubMed articles Google scholar articles
Miriam Mints Division of Obstetrics and Gynecology, Department of Women's and Children's health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
Lucio Bertario Unit of Hereditary Digestive Tract Tumors IRCCS, Istituto Nazionale Tumori, Milan, Italy PubMed articles Google scholar articles
Marta Pineda Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articles Google scholar articles
Matilde Navarro Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articles Google scholar articles
Monika Morak Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany MGZ—Medizinisch Genetisches Zentrum, Munich, Germany PubMed articles Google scholar articles
Laura Renkonen-Sinisalo Department of Surgery, Helsinki University Hospital, Helsinki, Finland Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland PubMed articles Google scholar articles
Ian M Frayling Institute of Medical Genetics, Cardiff University School of Medicine, Cardiff, UK PubMed articles Google scholar articles
John-Paul Plazzer Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Kirsi Pylvanainen Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland PubMed articles Google scholar articles
Maurizio Genuardi Institute of Genomic Medicine, “A. Gemelli” Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy PubMed articles Google scholar articles
Jukka-Pekka Mecklin Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland University of Eastern Finland, Jyvaskyla, Finland PubMed articles Google scholar articles
Gabriela Möslein Surgical Center for Hereditary Tumors, HELIOS University Clinic Wuppertal, University Witten-Herdecke, Wuppertal, Germany PubMed articles Google scholar articles
Julian R Sampson Institute of Medical Genetics, Cardiff University School of Medicine, Cardiff, UK PubMed articles Google scholar articles
Gabriel Capella Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articles Google scholar articles
in collaboration with The Mallorca Group ( )
Google scholar articles

Correspondence to Dr Pål Møller, Research Group Inherited Cancer, The Norwegian Radium Hospital, Oslo 0310, Norway; moller.pal{at}gmail.com

View Full Text

Citation

Møller P, Seppälä T, Bernstein I, et al

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

Gut 2017;66:1657-1664.

Publication history

Received January 4, 2016
Revised May 6, 2016
Accepted May 10, 2016
First published June 3, 2016.

Online issue publication

December 06, 2017

Abstract in Norwegian

This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

Abstract in Norwegian - Online abstract

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Abstract in Norwegian

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password