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Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis

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  • MS-T and PH contributed equally

  • Contributors Study concept and design: BCN, AVP, MS-T and PH. Acquisition, analysis or interpretation of data: all authors. Drafting of the manuscript: all authors. Critical revision of the manuscript for important intellectual content: all authors. Obtained funding: PH and MS-T. Administrative, technical or material support: all authors. Study supervision: BCN, MS-T and PH. Final approval of manuscript as submitted: all authors. Guarantors of the article: BCN and PH.

  • Funding Hungarian Scientific Research Fund (K116634); Momentum Grant of the Hungarian Academy of Sciences (LP2014-10/2014); and Gazdaságfejlesztési és Innovációs Operatív Program GINOP-2.3.2-15-2016-00015 (to PH); National Institutes of Health R01 DK058088 (to MS-T).

  • Competing interests None declared.

  • Ethics approval Scientific and Research Ethics Committee of the Medical Research Council of Hungary (22254-1/2012/EKU).

  • Provenance and peer review Not commissioned; internally peer reviewed.

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