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Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

Authors

  • Jonas Rosendahl Department of Internal Medicine I, Martin Luther University, Halle, Germany Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Holger Kirsten Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany PubMed articlesGoogle scholar articles
  • Eszter Hegyi Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Peter Kovacs Leipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Frank Ulrich Weiss Department of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany PubMed articlesGoogle scholar articles
  • Helmut Laumen Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Peter Lichtner Institute of Human Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany PubMed articlesGoogle scholar articles
  • Claudia Ruffert Department of Internal Medicine I, Martin Luther University, Halle, Germany PubMed articlesGoogle scholar articles
  • Jian-Min Chen Institut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) – Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d’Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France PubMed articlesGoogle scholar articles
  • Emmanuelle Masson Institut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) – Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d’Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France PubMed articlesGoogle scholar articles
  • Sebastian Beer Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Constantin Zimmer Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Katharina Seltsam Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Hana Algül Department of Gastroenterology, Technische Universität München (TUM), Munich, Germany PubMed articlesGoogle scholar articles
  • Florence Bühler Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Marco J Bruno Department of Gastroenterology & Hepatology, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Peter Bugert Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Ralph Burkhardt LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Giulia Martina Cavestro Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy PubMed articlesGoogle scholar articles
  • Halina Cichoz-Lach Department of Gastroenterology, Medical University of Lublin, Lublin, Poland PubMed articlesGoogle scholar articles
  • Antoni Farré Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Josef Frank Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Giovanni Gambaro Division of Nephrology and Dialysis, Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy PubMed articlesGoogle scholar articles
  • Sebastian Gimpfl Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Harald Grallert Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany PubMed articlesGoogle scholar articles
  • Heidi Griesmann Department of Internal Medicine I, Martin Luther University, Halle, Germany PubMed articlesGoogle scholar articles
  • Robert Grützmann Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Chirurgische Klinik, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Claus Hellerbrand Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany PubMed articlesGoogle scholar articles
  • Péter Hegyi Institute for Translational Medicine and First Department of Internal Medicine, University of Pécs, Pécs, Hungary HAS-SZTE, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary PubMed articlesGoogle scholar articles
  • Marcus Hollenbach Department of Internal Medicine I, Martin Luther University, Halle, Germany PubMed articlesGoogle scholar articles
  • Sevastitia Iordache Department of Internal Medicine and Gastroenterology, University of Medicine and Pharmacy, Craiova, Romania PubMed articlesGoogle scholar articles
  • Grazyna Jurkowska Department of Gastroenterology and Internal Medicine, Medical University Bialystok, Bialystok, Poland PubMed articlesGoogle scholar articles
  • Volker Keim Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Falk Kiefer Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Sebastian Krug Department of Internal Medicine I, Martin Luther University, Halle, Germany PubMed articlesGoogle scholar articles
  • Olfert Landt TIB MOLBIOL, Berlin, Germany PubMed articlesGoogle scholar articles
  • Milena Di Leo Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy PubMed articlesGoogle scholar articles
  • Markus M Lerch Department of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany PubMed articlesGoogle scholar articles
  • Philippe Lévy Pôle des Maladies de l’Appareil Digestif, Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, France PubMed articlesGoogle scholar articles
  • Markus Löffler Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Matthias Löhr Gastrocentrum, Karolinska Institutet CLINTEC, Stockholm, Sweden PubMed articlesGoogle scholar articles
  • Maren Ludwig Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Milan Macek Department of Biology and Medical Genetics, University Hospital Motol and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic PubMed articlesGoogle scholar articles
  • Nuria Malats Grupo de Epidemiología Genética y Molecular Programa de Genética del Cáncer Humano Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain CIBERONC, Spain PubMed articlesGoogle scholar articles
  • Ewa Malecka-Panas Department of Digestive Tract Diseases, Medical University of Łódź, Łódź, Poland PubMed articlesGoogle scholar articles
  • Giovanni Malerba Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy PubMed articlesGoogle scholar articles
  • Karl Mann Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Julia Mayerle Department of Medicine II, University Hospital,Ludwig-Maximilians-University Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Sonja Mohr Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Rene H M te Morsche Department of Gastroenterology and Hepatology, Radboud umc, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Marie Motyka Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Sebastian Mueller Department of Internal Medicine, Salem Medical Centre and Centre for Alcohol Research, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Thomas Müller Department of Pediatrics I, Medical University, Innsbruck, Austria PubMed articlesGoogle scholar articles
  • Markus M Nöthen Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Sergio Pedrazzoli Department of Medical and Surgical Sciences, IV Surgical Clinic, University of Padua, Padua, Italy PubMed articlesGoogle scholar articles
  • Stephen P Pereira Division of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK PubMed articlesGoogle scholar articles
  • Annette Peters Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany PubMed articlesGoogle scholar articles
  • Roland Pfützer Clinic for Internal Medicine, Hospital Döbeln, Döbeln, Germany PubMed articlesGoogle scholar articles
  • Francisco X Real CIBERONC, Spain Epithelial Carcinogenesis Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Vinciane Rebours Pôle des Maladies de l’Appareil Digestif, Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, France PubMed articlesGoogle scholar articles
  • Monika Ridinger Department of Psychiatry, University of Regensburg, Regensburg, Germany PubMed articlesGoogle scholar articles
  • Marcella Rietschel Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Eva Rösmann Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Adrian Saftoiu Department of Internal Medicine and Gastroenterology, University of Medicine and Pharmacy, Craiova, Romania PubMed articlesGoogle scholar articles
  • Alexander Schneider Department of Gastroenterology, Hepatology, Infectious Diseases, Medical Faculty of Mannheim University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Hans-Ulrich Schulz Department of Surgery, Otto-von-Guericke University Magdeburg, Magdeburg, Germany PubMed articlesGoogle scholar articles
  • Nicole Soranzo The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK Department of Haematology, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Michael Soyka Psychiatric Hospital, University of Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Peter Simon Department of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany PubMed articlesGoogle scholar articles
  • James Skipworth Department of Surgery and Interventional Science, University College London, London, UK PubMed articlesGoogle scholar articles
  • Felix Stickel Department of Gastroenterology and Hepatology, University Hospital of Zürich, Zürich, Switzerland PubMed articlesGoogle scholar articles
  • Konstantin Strauch Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany PubMed articlesGoogle scholar articles
  • Michael Stumvoll Leipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Pier Alberto Testoni Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy PubMed articlesGoogle scholar articles
  • Anke Tönjes Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Lena Werner Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Jens Werner Department of General, Visceral, and Transplant Surgery, Ludwig Maximilian University, Munich, Germany PubMed articlesGoogle scholar articles
  • Norbert Wodarz Department of Psychiatry, University of Regensburg, Regensburg, Germany PubMed articlesGoogle scholar articles
  • Martin Ziegler Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Atsushi Masamune Division of Gastroenterology, Tohoku University Graduate School of Medicine, SendaiMiyagi, Japan PubMed articlesGoogle scholar articles
  • Joachim Mössner Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Claude Férec Institut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) – Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d’Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France PubMed articlesGoogle scholar articles
  • Patrick Michl Department of Internal Medicine I, Martin Luther University, Halle, Germany PubMed articlesGoogle scholar articles
  • Joost P H Drenth Department of Gastroenterology and Hepatology, Radboud umc, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Heiko Witt Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany PubMed articlesGoogle scholar articles
  • Markus Scholz Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany PubMed articlesGoogle scholar articles
  • Miklós Sahin-Tóth Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
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  1. Correspondence to Professor Jonas Rosendahl, Department of Internal Medicine, Neurology and Dermatology Division of Gastroenterology and Rheumatology, University Clinic of Leipzig Liebigstraße 20, 04103 Leipzig, Germany; jonas.rosendahl{at}medizin.uni-leipzig.de
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Citation

Rosendahl J, Kirsten H, Hegyi E On behalf of all members of the PanEuropean Working group on ACP, et al
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

Publication history

  • Received May 5, 2017
  • Revised June 16, 2017
  • Accepted June 24, 2017
  • First published July 28, 2017.
Online issue publication 
September 07, 2018

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