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Original article
Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure
  1. Tianzhou Wu1,
  2. Jiang Li1,
  3. Li Shao1,
  4. Jiaojiao Xin1,
  5. Longyan Jiang1,
  6. Qian Zhou1,
  7. Dongyan Shi1,
  8. Jing Jiang1,
  9. Suwan Sun1,
  10. Linfeng Jin1,
  11. Ping Ye1,
  12. Lingling Yang1,
  13. Yinyun Lu1,
  14. Tan Li1,
  15. Jianrong Huang1,
  16. Xiaowei Xu1,
  17. Jiajia Chen1,
  18. Shaorui Hao1,
  19. Yuemei Chen1,
  20. Shaojie Xin2,
  21. Zhiliang Gao3,
  22. Zhongping Duan4,
  23. Tao Han5,
  24. Yuming Wang6,
  25. Jianhe Gan7,
  26. Tingting Feng7,
  27. Chen Pan8,
  28. Yongping Chen9,
  29. Hai Li10,
  30. Yan Huang11,
  31. Qing Xie12,
  32. Shumei Lin13,
  33. Lanjuan Li1,
  34. Jun Li1
  35. on behalf of the Chinese Group on the Study of Severe Hepatitis B (COSSH).
  1. 1 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
  2. 2 Department of Liver and Infectious Diseases, No. 302 Hospital of Chinese People’s Liberation Army, Beijing, China
  3. 3 Department of Liver and Infectious Diseases, The Third Affiliated Hospital, Sun YAT-SEN University, Guangzhou, China
  4. 4 Department of Liver and Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, China
  5. 5 Department of Liver and Infectious Diseases, Tianjin Third Central Hospital, Tianjin, China
  6. 6 Department of Liver and Infectious Diseases, The First Hospital Affiliated of The Third Military Medical University, Chongqing, China
  7. 7 Department of Liver and Infectious Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
  8. 8 Department of Liver and Infectious Diseases, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  9. 9 Department of Liver and Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  10. 10 Department of Gastroenterology, Renji Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China
  11. 11 Department of Liver and Infectious Diseases, Xiangya Hospital Central South University, Changsha, China
  12. 12 Department of Liver and Infectious Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China
  13. 13 Department of Liver and Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
  1. Correspondence to Professor Jun Li, Laboratory for Diagnosisand Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou,China; lijun2009{at}zju.edu.cn and Professor Lanjuan Li; ljli{at}zju.edu.cn

Footnotes

  • TW, JL and LS contributed equally.

  • Contributors TW, JL and LS contributed equally. The study was designed by JL and supervised by JL and LL. The manuscript was written by JL, TW, JL and LS. The experiment and data analysis were performed by JL, TW, JL, LS, JX, LJ, QZ, DS, JJ, SS, LJ, PY, LY, YL, TL, JH, XX, JC, SH, YC, SX, ZG, ZD, TH, YW, JG, TF, CP, YC, HL, YH, QX and SL. All authors were involved in critical revision of manuscript.

  • Funding This work was supported by National S&T Major Project of China (2012ZX10002004-001, 2017ZX10304402-002-002), National Natural Science Foundation of China (81571818/81771996) and Zhejiang Provincial and State’s Key Project of Research and Development Plan of China (2016YFC1101303/4, 2016C01G2010737).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Clinical Research Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • TW, JL and LS contributed equally.

  • Contributors TW, JL and LS contributed equally. The study was designed by JL and supervised by JL and LL. The manuscript was written by JL, TW, JL and LS. The experiment and data analysis were performed by JL, TW, JL, LS, JX, LJ, QZ, DS, JJ, SS, LJ, PY, LY, YL, TL, JH, XX, JC, SH, YC, SX, ZG, ZD, TH, YW, JG, TF, CP, YC, HL, YH, QX and SL. All authors were involved in critical revision of manuscript.

  • Funding This work was supported by National S&T Major Project of China (2012ZX10002004-001, 2017ZX10304402-002-002), National Natural Science Foundation of China (81571818/81771996) and Zhejiang Provincial and State’s Key Project of Research and Development Plan of China (2016YFC1101303/4, 2016C01G2010737).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Clinical Research Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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