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Tumour-associated and non-tumour-associated microbiota in colorectal cancer
  1. Hafid Omar Al-Hassi1,
  2. Oliver Ng2,
  3. Matthew Brookes3
  1. 1 Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton, UK
  2. 2 Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK
  3. 3 Gastroenterology Unit, Royal Wolverhampton NHS Trust, Wolverhampton, UK
  1. Correspondence to Dr Matthew Brookes, Department of Gastroenterology, New Cross Hospital, Royal Wolverhampton NHS Trust, Wednesfield Road, Wolverhampton WV10 OQP, West Mids, UK; m.j.brookes{at}

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We read with interest the elegant study published by Flemer et al 1 and commend the authors on their work. The authors provide convincing data to illustrate that faecal microbiota does not reflect accurately the underlying mucosal microbiota in patients with colorectal cancer (CRC).1 The authors also provide supporting evidence to illustrate that microbiota from sampled mucosa both on and off the cancer site is not significantly different. As previously demonstrated, they also provide corroboratory evidence to further conclude that microbiota is different in patients with CRC.

We are however concerned about the conclusions relating to the variability of mucosal microbiota based on tumour site. …

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  • Contributors All three authors have contributed to the review of the original article and the letter.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.