Statistics from Altmetric.com
The recent study by Wouters et al 1 reported that psychological status inversely correlates with immune profile in the development of postinfectious IBS. While there is increasing evidence of chronic low-grade immune activation in IBS, this field is mired in controversy.2 In our opinion, this contention is related to two major methodological issues: the tendency to group all patients with IBS together rather than stratifying according to bowel habit,3 and the overwhelming predominance of cross-sectional studies. We addressed these issues by performing a longitudinal study of patients with IBS comparing immune function within patients when symptom free and when they experience symptom flare.
Eleven subjects with long-standing IBS (initially characterised by ROME II criteria: 5 IBS-D, 4 IBS-A, 2 IBS-C; 10 female; 59±3 years (mean±SEM)) were enrolled sequentially from tertiary centres in Adelaide, Australia. Subjects completed a valid self-report Bowel Disease Questionnaire3 and …
Contributors CM, MAC and PAH performed the experiments and data analysis. JMA and PAB enrolled the patients. JMA, PAB and PAH designed the experiments and interpreted the data. PAH wrote the manuscript with input from all other authors.
Funding This study was supported by NHMRC Australia project grant #1042952 and NHMRC R.D. Wright Biomedical Fellowship #1105028 to PAH.
Competing interests None declared.
Patient consent Patient samples are deidentified.
Ethics approval Royal Adelaide Hospital Human Ethics Committee.
Provenance and peer review Not commissioned; internally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.