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Contributors CM, MAC and PAH performed the experiments and data analysis. JMA and PAB enrolled the patients. JMA, PAB and PAH designed the experiments and interpreted the data. PAH wrote the manuscript with input from all other authors.
Funding This study was supported by NHMRC Australia project grant #1042952 and NHMRC R.D. Wright Biomedical Fellowship #1105028 to PAH.
Competing interests None declared.
Patient consent Patient samples are deidentified.
Ethics approval Royal Adelaide Hospital Human Ethics Committee.
Provenance and peer review Not commissioned; internally peer reviewed.