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We recently read with great interest a review by Adams et al 1 showing that non-alcoholic fatty liver disease (NAFLD) has a profound impact on the onset of extrahepatic diseases, such as cardiovascular diseases and kidney diseases. We fully agree with this conclusion, and the authors have fully elucidated the relationship between NAFLD and extrahepatic diseases. We think that hepatokines produced and secreted by liver may play a critical role in NAFLD-related extrahepatic diseases, which would deepen the understanding of this disease.
Fibroblast growth factor 21 (FGF21), a hepatokine that is mainly secreted by the liver, has beneficial effects for improving metabolic …
Contributors RYJ and LY conceived the scientific idea and wrote the manuscript.
Funding This study was supported by the Program of Bureau of Science and Technology Foundation of Changzhou (No: CJ20159022) and CJ20160030) and Major Science and Technology Projects of Changzhou Municipal Committee of Health and Family Planning (No: ZD201505 and ZD201407).
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
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