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- gastric cancer
- circadian clock
- gene pathway
- genetic variation
- single nucleotide polymorphism (SNP)
- survival analysis
- prognostic factors
As we have summarised in this journal,1 germline DNA variation has been long recognised as a key component of the risk to develop to gastric carcinoma, the discovery pace being greatly accelerated by genome-wide association studies.2 More recently, growing evidence is accumulating also on the association between genetic variation and prognosis of patients with gastric cancer.3 4 Furthermore, investigators have demonstrated that alterations of the circadian rhythm can predispose to a variety of illnesses, including different types of malignancies and gastrointestinal diseases.5 6
Putting together these observations, we studied the relationship between circadian genes germline variation and the overall survival of 460 patients with TNM stage I to IV gastric carcinoma. We considered 21 single nucleotide polymorphisms (SNPs) of 14 circadian pathway genes. Genotyping was performed with real-time quantitative PCR using patient peripheral blood samples. Expression quantitative trait locus (eQTL) analysis was employed to …
Contributors SR: study design, genotyping experiments; CB: study design, article writing; HM: data collection, genotyping experiments; GS: data collection, genotyping experiments; CM: data analysis, article writing and SM: data analysis, article writing.
Competing interests None declared.
Patient consent Obtained.
Ethics approval University of Padova.
Provenance and peer review Not commissioned; internally peer reviewed.
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