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Original article
Leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer
  1. Manasi S Shah1,2,3,5,
  2. Todd Z DeSantis2,
  3. Thomas Weinmaier2,
  4. Paul J McMurdie2,4,
  5. Julia L Cope3,5,6,
  6. Adam Altrichter2,
  7. Jose-Miguel Yamal1,
  8. Emily B Hollister3,5
  1. 1Department of Epidemiology, University of Texas School of Public Health, Houston, Texas, USA
  2. 2Bioinformatics, Second Genome Inc, South San Francisco, California, USA
  3. 3Department of Pathology, Texas Children's Microbiome Center, Texas Children's Hospital, Houston, Texas, USA
  4. 4Bioinformatics, Whole Biome Inc, San Francisco, California, USA
  5. 5Department of Pathology and Immunology, Baylor College of Medicine, HoustonTexas, USA
  6. 6Diversigen, Inc, Houston, Texas, USA
  1. Correspondence to Dr Manasi S Shah, 3450 Central Expressway, Santa Clara, CA 95051, USA; manasishah86{at}gmail.com

Footnotes

  • Twitter Follow Manasi Shah @GoingByGut

  • Contributors MSS: Study design, data collection, sequence processing, statistical analysis and manuscript preparation. TDeS: Study design, data collection, sequence processing, statistical analysis and manuscript preparation. TW: Sequence processing and manuscript preparation. PJMcM: Statistical analysis and manuscript preparation. JLC: Sequence processing and manuscript preparation. AA: Statistical analysis and manuscript preparation. J-MY: Statistical analysis and manuscript preparation. EBH: Study design, data collection, sequence processing, statistical analysis and manuscript preparation.

  • Competing interests MSS worked as a consultant with Second Genome during the course of work. TDeS, TW, PJMcM and AA were employed by Second Genome during the course of the work and hold stock options.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Twitter Follow Manasi Shah @GoingByGut

  • Contributors MSS: Study design, data collection, sequence processing, statistical analysis and manuscript preparation. TDeS: Study design, data collection, sequence processing, statistical analysis and manuscript preparation. TW: Sequence processing and manuscript preparation. PJMcM: Statistical analysis and manuscript preparation. JLC: Sequence processing and manuscript preparation. AA: Statistical analysis and manuscript preparation. J-MY: Statistical analysis and manuscript preparation. EBH: Study design, data collection, sequence processing, statistical analysis and manuscript preparation.

  • Competing interests MSS worked as a consultant with Second Genome during the course of work. TDeS, TW, PJMcM and AA were employed by Second Genome during the course of the work and hold stock options.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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