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Prognosis of immune-tolerant phase chronic hepatitis B
  1. Chia-Ming Chu,
  2. Yun-Fan Liaw
  1. Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
  1. Correspondence to Professor Yun-Fan Liaw, Liver Research Unit, Chang Gung Memorial Hospital, Taipei 105, Taiwan; liveryfl{at}

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We read with great surprise the article by Kim et al 1  reporting high risks of hepatocellular carcinoma (HCC) and death in patients with untreated chronic hepatitis B who were classified by them as patients in ‘immune-tolerant’ (IT) phase. This conclusion contradicts to the general belief that there is little or no disease progression during the IT phase of chronic HBV infection, as best demonstrated in a 5-year histological follow-up study.2 Some issues of serious concern on this study, especially their IT phase patients, require clarification and further discussion to minimise misleading messages.

IT phase of perinatally acquired chronic HBV infection is typically seen in Asian children or young adults with high HBV DNA, normal alanine aminotransferase (ALT), hepatitis B e-antigen (HBeAg) seropositivity and normal or minimal …

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  • Contributors Both authors are the co-writers of this letter and contributed equally to this work.

  • Funding This study was supported by a grant from the Chang Gung Medical Research Program (CMRPG1G0061)

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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