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  • Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner

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Hepatology
Original article
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner

Authors

  • Palak J Trivedi National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK Liver Unit, University Hospitals Birmingham Queen Elizabeth, Birmingham, UK PubMed articlesGoogle scholar articles
  • Joseph Tickle National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK PubMed articlesGoogle scholar articles
  • Mette Nåmdal Vesterhus Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway PubMed articlesGoogle scholar articles
  • Peter J Eddowes National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK PubMed articlesGoogle scholar articles
  • Tony Bruns Department of Internal Medicine IV, University Hospital Jena, Germany Center for Sepsis Control and Care, University Hospital Jena, Germany PubMed articlesGoogle scholar articles
  • Jani Vainio Biotie Therapies Corp., Turku, Finland PubMed articlesGoogle scholar articles
  • Richard Parker National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK Liver Unit, University Hospitals Birmingham Queen Elizabeth, Birmingham, UK PubMed articlesGoogle scholar articles
  • David Smith Biotie Therapies Corp., Turku, Finland PubMed articlesGoogle scholar articles
  • Evaggelia Liaskou National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK PubMed articlesGoogle scholar articles
  • Liv Wenche Thorbjørnsen Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway PubMed articlesGoogle scholar articles
  • Gideon M Hirschfield National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK Liver Unit, University Hospitals Birmingham Queen Elizabeth, Birmingham, UK PubMed articlesGoogle scholar articles
  • Kaisa Auvinen MediCity Research Laboratory, University of Turku, Turku, Finland Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland PubMed articlesGoogle scholar articles
  • Stefan G Hubscher Department of Cellular Pathology, University Hospitals Birmingham Queen Elizabeth, Birmingham, UK PubMed articlesGoogle scholar articles
  • Marko Salmi MediCity Research Laboratory, University of Turku, Turku, Finland Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland PubMed articlesGoogle scholar articles
  • David H Adams National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK Liver Unit, University Hospitals Birmingham Queen Elizabeth, Birmingham, UK PubMed articlesGoogle scholar articles
  • Chris J Weston National Institute of Health Research Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Chris J Weston, National Institute of Health Research (NIHR) Birmingham Liver Biomedical Research Centre Institute of Immunology and Immunotherapy, University of Birmingham, Wolfson Drive, Birmingham B152TT, UK; c.j.weston{at}bham.ac.uk
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Citation

Trivedi PJ, Tickle J, Vesterhus MN, et al
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner
Gut 2018;67:1135-1145.

Publication history

  • Received May 31, 2016
  • Accepted March 23, 2017
  • First published April 20, 2017.
Online issue publication 
August 06, 2018

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/