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Letter
Genome-wide association studies identified loci contribute to phenotypic variance of gastric cancer
  1. Caiwang Yan1,
  2. Meng Zhu1,2,
  3. Tongtong Huang1,
  4. Fei Yu1,
  5. Guangfu Jin1,2
  1. 1 Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
  2. 2 Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China
  1. Correspondence to Dr Guangfu Jin, Department of Epidemiology and Biostatistics School of Public Health, Nanjing Medical University, Nanjing, 211166, China; guangfujin{at}njmu.edu.cn

https://doi.org/10.1136/gutjnl-2017-315230

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    We read with great interest the article by Mocellin et al,1 who conducted a comprehensive meta-analysis that nominated 11 germline variants at nine loci significantly associated with gastric cancer (GC) with high level of summary evidence. Moreover, they also identified 38 single nucleotide polymorphisms (SNPs) with intermediate quality significant associations. Most of these loci were resulted from hypothesis-driven studies based on biological relevance, but most of these studies were small sample size and might lead to publication bias. In order to further evaluate their relevance with GC in individual large studies, we analysed these variants directly or their strong linkage disequilibrium SNPs using existing genome-wide association study (GWAS) datasets (including 2631 cases and 4373 controls) in Chinese populations, including those from Nanjing and Beijing populations conducted by our group2 and from Henan and Shanxi populations conducted by the USA National Cancer Institute.3

    After exclusion of the …

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    Footnotes

    • CY and MZ contributed equally.

    • Contributors GJ designed the study and critically revised the manuscript for important intellectual content. MZ provided technical and data support. TH and FY performed data analysis. CY analysed data and wrote the manuscript.

    • Funding This work was supported by the national key research and development program of China (grant no. 2016YFC1302703); the national natural science foundation of China (grant nos. 81422042, 81373090); the key grant of natural science foundation of Jiangsu higher education institutions (grant no 15KJA330002); the Top-notch academic programs project of Jiangsu higher education institution (grant no. PPZY2015A067); and the priority academic program for the development of Jiangsu higher education institutions (public health and preventive medicine).

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval Institutional Review Board of Nanjing Medical University.

    • Provenance and peer review Not commissioned; externally peer reviewed.