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The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation

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  • X-YT and W-BZ contributed equally.

  • Contributors ZL, Z-SL, CF and J-MC designed the study. X-YT and W-BZ performed genetic analyses with the assistance of L-HH. EM established the modified inversion detection method. W-BZ and J-MC drafted the manuscript. All authors interpreted the data, revised the text and approved the final manuscript.

  • Funding Support for this study came from the National Natural Science Foundation of China (Grant Nos.81422010 and 81470884; to ZL), the Chang Jiang Scholars Program of Ministry of Education, China (Grant No. Q2015190; to ZL), Shanghai Pujiang Program (Grant No 17PJD044; to W-BZ), the Precision Medicine Program of the Second Military Medical University (Grant No 2017JZ02; to Z-SL), and the Institut National de la Santé et de la Recherche Médicale (INSERM), France.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethical committee of changhai hospital, Shanghai, China.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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