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X-YT and W-BZ contributed equally.
Contributors ZL, Z-SL, CF and J-MC designed the study. X-YT and W-BZ performed genetic analyses with the assistance of L-HH. EM established the modified inversion detection method. W-BZ and J-MC drafted the manuscript. All authors interpreted the data, revised the text and approved the final manuscript.
Funding Support for this study came from the National Natural Science Foundation of China (Grant Nos.81422010 and 81470884; to ZL), the Chang Jiang Scholars Program of Ministry of Education, China (Grant No. Q2015190; to ZL), Shanghai Pujiang Program (Grant No 17PJD044; to W-BZ), the Precision Medicine Program of the Second Military Medical University (Grant No 2017JZ02; to Z-SL), and the Institut National de la Santé et de la Recherche Médicale (INSERM), France.
Competing interests None declared.
Patient consent Obtained.
Ethics approval Ethical committee of changhai hospital, Shanghai, China.
Provenance and peer review Not commissioned; internally peer reviewed.
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