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Original article
IRTKS is correlated with progression and survival time of patients with gastric cancer
  1. Li-Yu Huang1,2,
  2. Xuefei Wang3,
  3. Xiao-Fang Cui2,
  4. He Li3,
  5. Junjie Zhao3,
  6. Chong-Chao Wu2,
  7. Lingqiang Min3,
  8. Zhicheng Zhou4,
  9. Lixin Wan5,
  10. Yu-Ping Wang6,
  11. Chao Zhang7,8,
  12. Wei-Qiang Gao4,
  13. Yihong Sun3,
  14. Ze-Guang Han1,2
  1. 1 Key Laboratory of Systems Biomedicine (Ministry of Education) and Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
  2. 2 Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
  3. 3 Department of General Surgery, Zhongshan Hospital, General Surgery Research Institute, Fudan University, Shanghai, China
  4. 4 State Key Laboratory of Oncogenes and Related Genes, School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China
  5. 5 Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
  6. 6 Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China
  7. 7 Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, USA
  8. 8 Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College of Cornell University, New York, USA
  1. Correspondence to Yihong Sun; sun.yihong{at}zs-hospital.sh.cn and Dr. Ze-Guang Han, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, China. ; hanzg{at}sjtu.edu.cn

Footnotes

  • L-YH, XW and X-FC contributed equally.

  • Contributors ZGH and LYH designed the experiments; LYH performed most of the animal and biochemical experiments; YS, XW, HL, JZ and LM collected and analysed patient samples; XFC, CCW and YPW performed some biochemical experiments; CZ analysed the biomedical information; LW, ZZ and WQG assisted in the analysis of some experiments. ZGH and LYH interpreted the data and wrote the manuscript.

  • Funding The study is supported from the National Natural ScienceFoundation of China (81402317, 81472621, 81672772, 81272271,81672324 and 31670806), and Science and Technology Commission ofShanghai Municipality (14ZR1429700 and 14140902500).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Zhongshan Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • L-YH, XW and X-FC contributed equally.

  • Contributors ZGH and LYH designed the experiments; LYH performed most of the animal and biochemical experiments; YS, XW, HL, JZ and LM collected and analysed patient samples; XFC, CCW and YPW performed some biochemical experiments; CZ analysed the biomedical information; LW, ZZ and WQG assisted in the analysis of some experiments. ZGH and LYH interpreted the data and wrote the manuscript.

  • Funding The study is supported from the National Natural ScienceFoundation of China (81402317, 81472621, 81672772, 81272271,81672324 and 31670806), and Science and Technology Commission ofShanghai Municipality (14ZR1429700 and 14140902500).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Zhongshan Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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