Footnotes

• Contributors BRS and MKR had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: BRS, MKW, CJP. Acquisition, analysis, interpretation of data: BRS, MKR, KS, EMR, RG, RCH. Drafting of the manuscript: BRS, MKR, CJP. Critical revision of the manuscript: BRS, MKW, CJP, KS, EMR, RCH. Statistical analysis: BRS, EMR. Obtained funding: BRS, MKR, CJP. Administrative, technical or material support: EMR, KS, CJP. Study supervision: BRS.

• Funding University of Florida Clinical and Translational Science Institute grant (BRS, CJP) from the National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR001427; National Institute of Health (NIH) grants HL33610, HL56921 (MKR, CJP); UM1 HL087366 (CJP); Gatorade Trust through funds distributed by the University of Florida, Department of Medicine (CJP); PCORI-OneFlorida Clinical Research Consortium CDRN-1501-26692 (CJP); and internal funds from the University of Florida Department of Physiology and Functional Genomics (BRS, MKR).

• Disclaimer The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

• Competing interests None declared.

• Patient consent Detail has been removed from this case description/these case descriptions to ensure anonymity. The editors and reviewers have seen the detailed information available and are satisfied that the information backs up the case the authors are making.

• Ethics approval The University of Florida Institutional Review Board approved the study.

• Provenance and peer review Not commissioned; internally peer reviewed.

• Data sharing statement Unpublished data may be accessed from the authors.

• Correction notice This article has been corrected since it was published Online First. Figure 2 has been replaced.